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    RPD3 histone deacetylase RPD3 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 855386, updated on 5-Jul-2015
    Gene symbol
    RPD3
    Gene description
    histone deacetylase RPD3
    Primary source
    SGD:S000005274
    Locus tag
    YNL330C
    Gene type
    protein coding
    RNA name
    histone deacetylase RPD3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MOF6; REC3; SDI2; SDS6
    See RPD3 in MapViewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (18001..19302, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Thi12p Neighboring gene Aad14p Neighboring gene AAA family ATPase peroxin 6 Neighboring gene Mdj2p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription coactivator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H4 deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone deacetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of chromatin silencing at rDNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chromatin silencing at silent mating-type cassette IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chromatin silencing at telomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of chromatin silencing at telomere IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription during meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase I promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to nucleolar rDNA repeats IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-dependent DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of DNA-dependent DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription involved in G1/S transition of mitotic cell cycle IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of transcription involved in G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription elongation from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transfer RNA gene-mediated silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Rpd3L complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rpd3L-Expanded complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rpd3S complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Sin3-type complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Snt2C complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    histone deacetylase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    histone deacetylase RPD3
    NP_014069.1
    • Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      18001..19302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183168.1NP_014069.1  histone deacetylase RPD3 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_014069.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32561
      Conserved Domains (2) summary
      cd10004
      Location:18392
      RPD3-like; reduced potassium dependency-3 (RPD3)-like
      PTZ00063
      Location:16433
      PTZ00063; histone deacetylase; Provisional