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    CYP3A4 cytochrome P450 family 3 subfamily A member 4 [ Homo sapiens (human) ]

    Gene ID: 1576, updated on 25-Sep-2016
    Official Symbol
    CYP3A4provided by HGNC
    Official Full Name
    cytochrome P450 family 3 subfamily A member 4provided by HGNC
    Primary source
    HGNC:HGNC:2637
    See related
    Ensembl:ENSG00000160868 HPRD:00484; MIM:124010; Vega:OTTHUMG00000156651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    7q21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (99756960..99784188, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99354583..99381811, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 25 Neighboring gene CYP3A7-CYP3A51P readthrough Neighboring gene cytochrome P450 family 3 subfamily A member 7 Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 5 pseudogene 2 Neighboring gene cytochrome P450 family 3 subfamily A member 137, pseudogene Neighboring gene cytochrome P450 family 3 subfamily A member 43

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Clozapine response
    MedGen: CN077971 GeneReviews: Not available
    Compare labs
    Esomeprazole response
    MedGen: CN077982 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Human metabolic individuality in biomedical and pharmaceutical research.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    Knockdown of cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126680

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    albendazole monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    caffeine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    estrogen 16-alpha-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monooxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxygen binding TAS
    Traceable Author Statement
    more info
     
    quinine 3-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    taurochenodeoxycholate 6alpha-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    testosterone 6-beta-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vitamin D 24-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vitamin D3 25-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    alkaloid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    androgen metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    calcitriol biosynthetic process from calciol IEA
    Inferred from Electronic Annotation
    more info
     
    drug catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    exogenous drug catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heterocycle metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid hydroxylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    monoterpenoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidative demethylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    steroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vitamin D metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle TAS
    Traceable Author Statement
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 3A4
    Names
    1,8-cineole 2-exo-monooxygenase
    P450-III, steroid inducible
    albendazole monooxygenase
    albendazole sulfoxidase
    cholesterol 25-hydroxylase
    cytochrome P450 3A3
    cytochrome P450 HLp
    cytochrome P450 NF-25
    cytochrome P450, family 3, subfamily A, polypeptide 4
    cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
    cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
    cytochrome P450-PCN1
    glucocorticoid-inducible P450
    nifedipine oxidase
    quinine 3-monooxygenase
    taurochenodeoxycholate 6-alpha-hydroxylase
    NP_001189784.1
    NP_059488.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008421.1 RefSeqGene

      Range
      4998..32226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202855.2NP_001189784.1  cytochrome P450 3A4 isoform 2

      See identical proteins and their annotated locations for NP_001189784.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the CDS compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC069294, BC101631, J04449
      UniProtKB/Swiss-Prot
      P08684
      UniProtKB/TrEMBL
      Q6GRK0
      Conserved Domains (1) summary
      pfam00067
      Location:39492
      p450; Cytochrome P450
    2. NM_017460.5NP_059488.2  cytochrome P450 3A4 isoform 1

      See identical proteins and their annotated locations for NP_059488.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC069294, AK312967
      Consensus CDS
      CCDS5674.1
      UniProtKB/Swiss-Prot
      P08684
      UniProtKB/TrEMBL
      Q6GRK0
      Related
      ENSP00000337915, OTTHUMP00000210308, ENST00000336411, OTTHUMT00000345059
      Conserved Domains (1) summary
      pfam00067
      Location:39493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      99756960..99784188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011780.1XP_016867269.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      99284687..99311925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001202856.1: Suppressed sequence

      Description
      NM_001202856.1: This RefSeq was permanently suppressed because it represents a product of trans-splicing and is not in scope for the RefSeq collection.
    2. NM_001202857.1: Suppressed sequence

      Description
      NM_001202857.1: This RefSeq was permanently suppressed because it represents a product of trans-splicing and is not in scope for the RefSeq collection.
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