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    Hmox1 heme oxygenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 15368, updated on 17-Jul-2016
    Official Symbol
    Hmox1provided by MGI
    Official Full Name
    heme oxygenase 1provided by MGI
    Primary source
    MGI:MGI:96163
    See related
    Ensembl:ENSMUSG00000005413 Vega:OTTMUSG00000030644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HO1; HO-1; Hmox; Hemox; Hsp32; D8Wsu38e
    Orthologs
    Location:
    8 35.59 cM; 8 C1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (75093618..75100593)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (77617517..77624492)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene target of myb1 trafficking protein Neighboring gene dpy-30 homolog pseudogene Neighboring gene minichromosome maintenance complex component 5 Neighboring gene RASD family, member 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    heme oxygenase (decyclizing) activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell death ISO
    Inferred from Sequence Orthology
    more info
     
    cellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to arsenic-containing substance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to cisplatin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    heme metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heme oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of macroautophagy IMR PubMed 
    negative regulation of mast cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to iron IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    heme oxygenase 1
    Names
    P32 protein
    heme oxygenase (decycling) 1
    hemoxygenase
    NP_034572.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010442.2NP_034572.1  heme oxygenase 1

      See identical proteins and their annotated locations for NP_034572.1

      Status: VALIDATED

      Source sequence(s)
      AA186175, AK150934, BY319630
      Consensus CDS
      CCDS22423.1
      UniProtKB/Swiss-Prot
      P14901
      UniProtKB/TrEMBL
      Q3U5U6
      Related
      ENSMUSP00000005548, OTTMUSP00000039843, ENSMUST00000005548, OTTMUST00000075866
      Conserved Domains (1) summary
      cd00232
      Location:12218
      HemeO; Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      75093618..75100593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)