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Gad2 glutamic acid decarboxylase 2 [ Mus musculus (house mouse) ]

Gene ID: 14417, updated on 19-May-2015
Official Symbol
Gad2provided by MGI
Official Full Name
glutamic acid decarboxylase 2provided by MGI
Primary source
MGI:MGI:95634
See related
Ensembl:ENSMUSG00000026787; Vega:OTTMUSG00000011505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GAD65; Gad-2; GAD(65); 6330404F12Rik
Orthologs
See Gad2 in MapViewer
Location:
2 A3; 2 15.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (22621423..22693877)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (22477847..22549397)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene myosin IIIA Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene myosin IIIA Neighboring gene microRNA 3967 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3-like Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein Neighboring gene predicted gene, 39768

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
glutamate decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutamate decarboxylation to succinate ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
anchored component of membrane ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
inhibitory synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutamate decarboxylase 2
Names
glutamate decarboxylase 2
65 kDa glutamic acid decarboxylase
GAD-65
glutamate decarboxylase 65 kDa isoform
NP_032104.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008078.2NP_032104.2  glutamate decarboxylase 2

    See identical proteins and their annotated locations for NP_032104.2

    Status: VALIDATED

    Source sequence(s)
    AL928693, BC018380, BQ571205
    Consensus CDS
    CCDS15724.1
    UniProtKB/Swiss-Prot
    P48320
    UniProtKB/TrEMBL
    Q548L4
    Related
    ENSMUSP00000028123, OTTMUSP00000012268, ENSMUST00000028123, OTTMUST00000026891
    Conserved Domains (1) summary
    cd06450
    Location:178581
    DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    22621423..22693877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239023.1XP_011237325.1  

    Conserved Domains (1) summary
    cl18945
    Location:138310
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    22352193..22424544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)