Display Settings:

Format

Send to:

Choose Destination

Cebpb CCAAT/enhancer binding protein (C/EBP), beta [ Mus musculus (house mouse) ]

Gene ID: 12608, updated on 17-Jan-2015
Official Symbol
Cebpbprovided by MGI
Official Full Name
CCAAT/enhancer binding protein (C/EBP), betaprovided by MGI
Primary source
MGI:MGI:88373
Locus tag
RP24-151H6.1
See related
Ensembl:ENSMUSG00000056501; Vega:OTTMUSG00000016307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LAP; LIP; CRP2; NF-M; Nfil6; NF-IL6; IL-6DBP; C/EBPbeta
See Cebpb in Epigenomics, MapViewer
Location:
2 H3; 2 87.58 cM
Exon count:
1
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (167688915..167690418)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 189 Neighboring gene predicted gene, 31932 Neighboring gene RIKEN cDNA A530013C23 gene Neighboring gene uncharacterized LOC102634439

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
embryonic placenta development IGI
Inferred from Genetic Interaction
more info
PubMed 
fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
mammary gland epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of interleukin-6 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription involved in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
CCAAT/enhancer-binding protein beta
Names
CCAAT/enhancer-binding protein beta
AGP/EBP
C/EBP BETA
nuclear protein Il6
interleukin-6-dependent-binding protein
liver-enriched transcriptional activator

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287738.1NP_001274667.1  CCAAT/enhancer-binding protein beta isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (b, also known as LAP) represented in this RefSeq results from translation initiation at the second in-frame AUG start codon. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL935060
    UniProtKB/Swiss-Prot
    P28033
    Conserved Domains (1) summary
    cd12193
    Location:206255
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins
  2. NM_001287739.1NP_001274668.1  CCAAT/enhancer-binding protein beta isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (c, also known as LIP) represented in this RefSeq results from translation initiation at the third in-frame AUG start codon. Isoform c has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AL935060
    UniProtKB/Swiss-Prot
    P28033
    Conserved Domains (1) summary
    pfam07716
    Location:71123
    bZIP_2; Basic region leucine zipper
  3. NM_009883.4NP_034013.1  CCAAT/enhancer-binding protein beta isoform a

    See proteins identical to NP_034013.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes multiple isoforms through the use of alternative translation initiation codons. The isoform (a, also known as LAP*) represented in this RefSeq results from translation initiation at the 5' most AUG start codon and is the longest isoform.
    Source sequence(s)
    AL935060
    Consensus CDS
    CCDS17105.1
    UniProtKB/Swiss-Prot
    P28033
    UniProtKB/TrEMBL
    Q3UPN9
    Related
    ENSMUSP00000069850, OTTMUSP00000017503, ENSMUST00000070642, OTTMUST00000039186
    Conserved Domains (1) summary
    cd12193
    Location:227276
    B_zip1; basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    167688915..167690418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    173629112..173630498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)