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    Itgb4 integrin beta 4 [ Mus musculus (house mouse) ]

    Gene ID: 192897, updated on 27-Aug-2016
    Official Symbol
    Itgb4provided by MGI
    Official Full Name
    integrin beta 4provided by MGI
    Primary source
    MGI:MGI:96613
    See related
    Ensembl:ENSMUSG00000020758 Vega:OTTMUSG00000003650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD104; AA407042; C230078O20
    Summary
    Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (115974725..116008412)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115836039..115869725)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RecQ protein-like 5 Neighboring gene small integral membrane protein 6 Neighboring gene SAP30 binding protein Neighboring gene predicted gene, 39474 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene galactokinase 1 Neighboring gene H3 histone, family 3B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to insulin-like growth factor I binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to neuregulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    amelogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemidesmosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    nail development ISO
    Inferred from Sequence Orthology
    more info
     
    renal system development ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding ISO
    Inferred from Sequence Orthology
    more info
     
    skin development ISO
    Inferred from Sequence Orthology
    more info
     
    trophoblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basement membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    hemidesmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hemidesmosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integrin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005608.2NP_001005608.2  integrin beta-4 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA407046, AK048888, AK147424, BE863493
      Consensus CDS
      CCDS36376.1
      UniProtKB/TrEMBL
      A2A864
      Related
      ENSMUSP00000127604, ENSMUST00000169928
      Conserved Domains (6) summary
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:12181311
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:16221707
      fn3; Fibronectin type III domain
      pfam00362
      Location:38455
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:628710
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:545575
      EGF_2; EGF-like domain
    2. NM_133663.2NP_598424.2  integrin beta-4 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different splice site and lacks an alternate in-frame exon in the 3' coding region, as compared to variant 1. The resulting protein (isoform 2) thus has two differences with a shorter C-terminus when compared to isoform 1.
      Source sequence(s)
      AA407046, AK048888, AK147424
      Conserved Domains (5) summary
      pfam06524
      Location:514639
      NOA36; NOA36 protein
      smart00237
      Location:9911085
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:14581539
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07965
      Location:628712
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      115974725..116008412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532574.2XP_006532637.1  

      UniProtKB/Swiss-Prot
      A2A863
      Related
      ENSMUSP00000070811, OTTMUSP00000003826, ENSMUST00000068981, OTTMUST00000007884
      Conserved Domains (6) summary
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:12221315
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:15731658
      fn3; Fibronectin type III domain
      pfam00362
      Location:38455
      Integrin_beta; Integrin, beta chain
      pfam07965
      Location:628711
      Integrin_B_tail; Integrin beta tail domain
      pfam07974
      Location:547575
      EGF_2; EGF-like domain
    2. XM_017314349.1XP_017169838.1  

    3. XM_006532572.3XP_006532635.1  

      See identical proteins and their annotated locations for XP_006532635.1

      UniProtKB/Swiss-Prot
      A2A863
      Related
      ENSMUSP00000102069, ENSMUST00000106461
      Conserved Domains (5) summary
      pfam06524
      Location:514639
      NOA36; NOA36 protein
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15241605
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07965
      Location:628713
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    4. XM_006532573.3XP_006532636.1  

      UniProtKB/Swiss-Prot
      A2A863
      Related
      ENSMUSP00000102068, OTTMUSP00000003827, ENSMUST00000106460, OTTMUST00000007885
      Conserved Domains (5) summary
      pfam06524
      Location:514639
      NOA36; NOA36 protein
      smart00237
      Location:9921086
      Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
      cd00063
      Location:15121593
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07965
      Location:628713
      Integrin_B_tail; Integrin beta tail domain
      cl00057
      Location:38455
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    5. XM_017314351.1XP_017169840.1  

    6. XM_017314350.1XP_017169839.1