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PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) [ Homo sapiens (human) ]

Gene ID: 5742, updated on 7-Dec-2014
Official Symbol
PTGS1provided by HGNC
Official Full Name
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)provided by HGNC
Primary source
HGNC:HGNC:9604
Locus tag
RP11-542K23.6
See related
Ensembl:ENSG00000095303; HPRD:07518; MIM:176805; Vega:OTTHUMG00000020605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
See PTGS1 in Epigenomics, MapViewer
Location:
9q32-q33.3
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (122370530..122395703)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125132809..125157982)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene LIM homeobox 6 Neighboring gene RNA binding motif protein 18 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene olfactory receptor, family 1, subfamily J, member 2 Neighboring gene olfactory receptor, family 1, subfamily J, member 1 Neighboring gene olfactory receptor, family 1, subfamily J, member 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 increases the intracellular concentrations of prostaglandin E2 and leukotriene B4 by upregulating the activity and expression of the arachidonate-metabolizing enzymes prostaglandin H synthase and 5-lipoxygenase, respectively PubMed
env Preincubation of human astrocytoma cells with HIV-1 gp120 produces a significant increase of nitrite and PGE2 in cell supernatants; the effect of gp120 on both nitrite and PGE2 production is inhibited by antagonists of NO synthase or cyclooxygenase PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity TAS
Traceable Author Statement
more info
 
prostaglandin-endoperoxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-endoperoxide synthase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
cyclooxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
prostaglandin G/H synthase 1
Names
prostaglandin G/H synthase 1
PGH synthase 1
cyclooxygenase-1
prostaglandin H2 synthase 1
NP_000953.2
NP_001258093.1
NP_001258094.1
NP_001258095.1
NP_001258296.1
NP_001258297.1
NP_542158.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032900.1 

    Range
    4581..29754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000962.3NP_000953.2  prostaglandin G/H synthase 1 isoform 1 precursor

    See proteins identical to NP_000953.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI813317, AL162424, AL359636, DA392280, M59979
    Consensus CDS
    CCDS6842.1
    UniProtKB/Swiss-Prot
    P23219
    Related
    ENSP00000354612, OTTHUMP00000022052, ENST00000362012, OTTHUMT00000053933
    Conserved Domains (3) summary
    cd09816
    Location:89575
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3269
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:145581
    An_peroxidase; Animal haem peroxidase
  2. NM_001271164.1NP_001258093.1  prostaglandin G/H synthase 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region, compared to isoform 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AI813317, AL162424, AL359636, CD014048, DA392280
    Consensus CDS
    CCDS75895.1
    UniProtKB/TrEMBL
    A0A087X296
    Related
    ENSP00000484800, ENST00000614910
    Conserved Domains (3) summary
    cd09816
    Location:89527
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3269
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:138533
    An_peroxidase; Animal haem peroxidase
  3. NM_001271165.1NP_001258094.1  prostaglandin G/H synthase 1 isoform 4

    See proteins identical to NP_001258094.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate downstream in-frame start site, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI813317, AK290022, AK304403, AL359636
    Consensus CDS
    CCDS59521.1
    UniProtKB/Swiss-Prot
    P23219
    Related
    ENSP00000362802, ENST00000373698
    Conserved Domains (2) summary
    cd09816
    Location:2466
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam03098
    Location:36472
    An_peroxidase; Animal haem peroxidase
  4. NM_001271166.1NP_001258095.1  prostaglandin G/H synthase 1 isoform 5

    See proteins identical to NP_001258095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. These differences result in initiation of translation at an alternate downstream in-frame start site, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AI813317, AK295221, AK308222, AL162424, AL359636
    UniProtKB/Swiss-Prot
    P23219
    Conserved Domains (2) summary
    cd09816
    Location:2429
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam03098
    Location:36435
    An_peroxidase; Animal haem peroxidase
  5. NM_001271367.1NP_001258296.1  prostaglandin G/H synthase 1 isoform 5

    See proteins identical to NP_001258296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate splice sites at internal exons, compared to variant 1. These differences result in initiation of translation at an alternate downstream in-frame start site, compared to variant 1. The primary ORF can be translated due to a combination of reinitiation and leaky scanning. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AI813317, AL162424, AL359636, CD014049, DA392280
    Conserved Domains (2) summary
    cd09816
    Location:2429
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    pfam03098
    Location:36435
    An_peroxidase; Animal haem peroxidase
  6. NM_001271368.1NP_001258297.1  prostaglandin G/H synthase 1 isoform 6

    See proteins identical to NP_001258297.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start site, compared to variant 1. The primary ORF can be translated due to a combination of reinitiation and leaky scanning. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AI813317, AK295221, AK308222, AL162424, AL359636
    Consensus CDS
    CCDS59520.1
    UniProtKB/Swiss-Prot
    P23219
    Related
    ENSP00000437709, ENST00000540753
    Conserved Domains (3) summary
    cd09816
    Location:64513
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:844
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:120519
    An_peroxidase; Animal haem peroxidase
  7. NM_080591.2NP_542158.1  prostaglandin G/H synthase 1 isoform 2 precursor

    See proteins identical to NP_542158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI813317, AL162424, AL359636, DA392280, S36219
    Consensus CDS
    CCDS6843.1
    UniProtKB/Swiss-Prot
    P23219
    Conserved Domains (3) summary
    cd09816
    Location:89538
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3269
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:145544
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    122370530..122395703
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252105.1XP_005252162.1  

    See proteins identical to XP_005252162.1

    Conserved Domains (3) summary
    cd09816
    Location:64550
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:844
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:120556
    An_peroxidase; Animal haem peroxidase
  2. XM_006717192.1XP_006717255.1  

    See proteins identical to XP_006717255.1

    UniProtKB/Swiss-Prot
    P23219
    Conserved Domains (3) summary
    cd09816
    Location:64513
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:844
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:120519
    An_peroxidase; Animal haem peroxidase

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    125280871..125306038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    94747532..94772698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)