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Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13115, updated on 30-Jun-2014
Official Symbol
Cyp27b1provided by MGI
Official Full Name
cytochrome P450, family 27, subfamily b, polypeptide 1provided by MGI
Primary source
MGI:1098274
See related
Ensembl:ENSMUSG00000006724; Vega:OTTMUSG00000035227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vdr; Cp2b; Cyp1; Pddr; Vdd1; Vddr; Cyp40; VddrI; Cyp27b; P450c1
See Cyp27b1 in Epigenomics, MapViewer
Location:
10 D3; 10
Exon count :
9
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 10 NC_000076.6 (127048246..127053422)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene protein FAM119B-like Neighboring gene methyltransferase like 1 Neighboring gene membrane-associated ring finger (C3HC4) 9 Neighboring gene cyclin-dependent kinase 4 Neighboring gene tetraspanin 31

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcidiol 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
aging ISO
Inferred from Sequence Orthology
more info
 
calcitriol biosynthetic process from calciol IDA
Inferred from Direct Assay
more info
PubMed 
calcitriol biosynthetic process from calciol ISO
Inferred from Sequence Orthology
more info
 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
response to cAMP ISO
Inferred from Sequence Orthology
more info
 
response to copper ion ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to prostaglandin E ISO
Inferred from Sequence Orthology
more info
 
response to vitamin D IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
vitamin D catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D catabolic process ISO
Inferred from Sequence Orthology
more info
 
vitamin D metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Names
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
P450VD1alpha
1alpha(OH)ase
VD3 1A hydroxylase
cytochrome p450 27B1
cytochrome P450, 27b1
cytochrome P450C1 alpha
cytochrome P450VD1-alpha
calcidiol 1-monooxygenase
25(OH)D 1alpha-hydroxylase
25-OHD-1 alpha-hydroxylase
25-hydroxyvitamin D3 1alpha-hydroxylase
25-hydroxyvitamin D(3) 1-alpha-hydroxylase
cytochrome P450 subfamily XXVIIB polypeptide 1
cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase)
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D3 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha)
NP_034139.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010009.2NP_034139.2  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

    See proteins identical to NP_034139.2

    Status: VALIDATED

    Source sequence(s)
    AB006034, BC080697, BM119774, CF168641
    Consensus CDS
    CCDS24224.2
    UniProtKB/Swiss-Prot
    O35084
    UniProtKB/TrEMBL
    Q66JY8
    Related
    ENSMUSP00000130005, OTTMUSP00000049096, ENSMUST00000165764, OTTMUST00000089781
    Conserved Domains (1) summary
    pfam00067
    Location:41504
    Blast Score: 727
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000076.6 

    Range
    127048246..127053422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513187.1XP_006513250.1  

    Conserved Domains (1) summary
    pfam00067
    Location:116437
    Blast Score: 659
    p450; Cytochrome P450

Alternate Mm_Celera

Genomic

  1. AC_000032.1 

    Range
    129440145..129444905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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