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    NLRP3 NLR family pyrin domain containing 3 [ Homo sapiens (human) ]

    Gene ID: 114548, updated on 15-Jun-2016
    Official Symbol
    NLRP3provided by HGNC
    Official Full Name
    NLR family pyrin domain containing 3provided by HGNC
    Primary source
    HGNC:HGNC:16400
    See related
    Ensembl:ENSG00000162711 HPRD:05915; MIM:606416; Vega:OTTHUMG00000040647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AII; AVP; FCU; MWS; FCAS; CIAS1; FCAS1; NALP3; C1orf7; CLR1.1; PYPAF1; AGTAVPRL
    Summary
    This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
    Orthologs
    Location:
    1q44
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (247416156..247449108)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247579247..247612410)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC107985374 Neighboring gene uncharacterized LOC107985375 Neighboring gene olfactory receptor family 2 subfamily B member 11 Neighboring gene olfactory receptor family 2 subfamily W member 5 (gene/pseudogene)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Chronic infantile neurological, cutaneous and articular syndrome
    MedGen: C0409818 OMIM: 607115 GeneReviews: Not available
    Compare labs
    Familial amyloid nephropathy with urticaria AND deafness
    MedGen: C0268390 OMIM: 191900 GeneReviews: Not available
    Compare labs
    Familial cold urticaria
    MedGen: C0343068 OMIM: 120100 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for reading and language abilities in two population cohorts.
    NHGRI GWA Catalog
    Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
    NHGRI GWA Catalog
    Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 inhibitors T20, NVP, AZT, and raltegravir significantly attenuate HIV-1-induced IL-1B production and NLRP3 activation, suggesting that HIV-1 gp41, RT, and IN are required for pro-IL-1B expression and NLRP3 activation PubMed
    integrase gag-pol HIV-1 inhibitors T20, NVP, AZT, and raltegravir significantly attenuate HIV-1-induced IL-1B production and NLRP3 activation, suggesting that HIV-1 gp41, RT, and IN are required for pro-IL-1B expression and NLRP3 activation PubMed
    reverse transcriptase gag-pol HIV-1 inhibitors T20, NVP, AZT, and raltegravir significantly attenuate HIV-1-induced IL-1B production and NLRP3 activation, suggesting that HIV-1 gp41, RT, and IN are required for pro-IL-1B expression and NLRP3 activation PubMed

    Go to the HIV-1, Human Interaction Database

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammasomes, organism-specific biosystem (from REACTOME)
      Inflammasomes, organism-specific biosystemIn contrast to NOD1/2 some NLRPs function as large macromolecular complexes called 'Inflammasomes'. These multiprotein platforms control activation of the cysteinyl aspartate protease caspase-1 and t...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • NOD pathway, organism-specific biosystem (from WikiPathways)
      NOD pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
      NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
    • Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
      Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • The NLRP3 inflammasome, organism-specific biosystem (from REACTOME)
      The NLRP3 inflammasome, organism-specific biosystemThe NLRP3 (Cryopyrin) inflammasome is currently the best characterized. It consists of NLRP3, ASC (PYCARD) and procaspase-1; CARD8 (Cardinal) is also suggested to be a component. It is activated by a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ95925

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    peptidoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    NLRP3 inflammasome complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    detection of biotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-1 secretion IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-18 production IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NF-kappaB import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-1 beta secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T-helper 17 cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of T-helper 2 cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T-helper 2 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-1 beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of type 2 immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein oligomerization TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NLRP3 inflammasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3
    Names
    NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
    NACHT, LRR and PYD containing protein 3
    NLR family, pyrin domain containing 3
    PYRIN-containing APAF1-like protein 1
    caterpiller protein 1.1
    cold autoinflammatory syndrome 1 protein
    cold-induced autoinflammatory syndrome 1 protein
    cryopyrin
    nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007509.2 RefSeqGene

      Range
      4984..37936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_197

    mRNA and Protein(s)

    1. NM_001079821.2NP_001073289.1  NACHT, LRR and PYD domains-containing protein 3 isoform a

      See identical proteins and their annotated locations for NP_001073289.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AF410477, AF420469, AK314998, AL606804
      Consensus CDS
      CCDS1632.1
      UniProtKB/Swiss-Prot
      Q96P20
      Related
      ENSP00000375704, OTTHUMP00000038410, ENST00000391828, OTTHUMT00000097742
      Conserved Domains (7) summary
      COG4886
      Location:739924
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:575951
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:913981
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_001127461.2NP_001120933.1  NACHT, LRR and PYD domains-containing protein 3 isoform c

      See identical proteins and their annotated locations for NP_001120933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AB208891, AC104335, AF420469, AK314998, AL606804
      Consensus CDS
      CCDS44346.1
      UniProtKB/Swiss-Prot
      Q96P20
      Related
      ENSP00000355453, ENST00000366497
      Conserved Domains (7) summary
      COG4886
      Location:719867
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:575979
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:856924
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743764
      LRR_RI; leucine-rich repeat [structural motif]
    3. NM_001127462.2NP_001120934.1  NACHT, LRR and PYD domains-containing protein 3 isoform d

      See identical proteins and their annotated locations for NP_001120934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the mid-coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AC104335, AF410477, AF420469, AL606804, AY422168
      Consensus CDS
      CCDS44347.1
      UniProtKB/Swiss-Prot
      Q96P20
      Related
      ENSP00000375703, OTTHUMP00000038411, ENST00000391827, OTTHUMT00000097743
      Conserved Domains (8) summary
      smart00368
      Location:911938
      LRR_RI; Leucine rich repeat, ribonuclease inhibitor type
      cd00116
      Location:575894
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:856924
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:699719
      LRR_AMN1; leucine-rich repeat [structural motif]
    4. NM_001243133.1NP_001230062.1  NACHT, LRR and PYD domains-containing protein 3 isoform e

      See identical proteins and their annotated locations for NP_001230062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) is identical to variant 1 but uses a downstream start codon. The resulting protein (isoform e) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC104335, AF410477, AF420469, AF427617, AL606804
      UniProtKB/Swiss-Prot
      Q96P20
      Conserved Domains (7) summary
      COG4886
      Location:737922
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:573949
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:218387
      NACHT; NACHT domain
      pfam13855
      Location:911979
      LRR_8; Leucine rich repeat
      pfam14484
      Location:142207
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:891
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:741769
      LRR_RI; leucine-rich repeat [structural motif]
    5. NM_004895.4NP_004886.3  NACHT, LRR and PYD domains-containing protein 3 isoform a

      See identical proteins and their annotated locations for NP_004886.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC104335, AF410477, AF420469, AF427617, AL606804
      Consensus CDS
      CCDS1632.1
      UniProtKB/Swiss-Prot
      Q96P20
      Related
      ENSP00000337383, OTTHUMP00000038408, ENST00000336119, OTTHUMT00000097740
      Conserved Domains (7) summary
      COG4886
      Location:739924
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:575951
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:913981
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
    6. NM_183395.2NP_899632.1  NACHT, LRR and PYD domains-containing protein 3 isoform b

      See identical proteins and their annotated locations for NP_899632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons, which are located in the mid-coding and 3' coding regions, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC104335, AF410477, AF420469, AF427617, AL606804, AY092033
      Consensus CDS
      CCDS1633.1
      UniProtKB/Swiss-Prot
      Q96P20
      Related
      ENSP00000294752, OTTHUMP00000038409, ENST00000348069, OTTHUMT00000097741
      Conserved Domains (7) summary
      cd00116
      Location:575922
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:799867
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:699719
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      247416156..247449108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000183.1XP_016855672.1  

    2. XM_017000184.1XP_016855673.1  

    3. XM_017000182.1XP_016855671.1  

    4. XM_011544053.2XP_011542355.1  

      Conserved Domains (7) summary
      cd00116
      Location:575922
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:799867
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:699719
      LRR_AMN1; leucine-rich repeat [structural motif]
    5. XM_011544055.2XP_011542357.1  

      Conserved Domains (6) summary
      cd00116
      Location:575865
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:742810
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]
    6. XM_017000181.1XP_016855670.1  

    7. XM_011544048.2XP_011542350.1  

      See identical proteins and their annotated locations for XP_011542350.1

      UniProtKB/Swiss-Prot
      Q96P20
      Conserved Domains (7) summary
      COG4886
      Location:739924
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:575951
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:220389
      NACHT; NACHT domain
      pfam13855
      Location:913981
      LRR_8; Leucine rich repeat
      pfam14484
      Location:144209
      FISNA; Fish-specific NACHT associated domain
      cd08320
      Location:1093
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:743771
      LRR_RI; leucine-rich repeat [structural motif]

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      248851104..248884745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)