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IST2 Ist2p [ Saccharomyces cerevisiae S288c ]

Gene ID: 852382, updated on 6-Jul-2014
Gene symbol
IST2
Gene description
Ist2p
Primary source
SGD:S000000290
Locus tag
YBR086C
Gene type
protein coding
RNA name
Ist2p
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See IST2 in MapViewer
Location:
chromosome: II
Exon count:
1
Sequence:
Chromosome: II; NC_001134.8 (420201..423041, complement)

Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Aac3p Neighboring gene hypothetical protein Neighboring gene replication factor C subunit 5 Neighboring gene Pol30p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
lipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
endoplasmic reticulum membrane organization IGI
Inferred from Genetic Interaction
more info
 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 
regulation of phosphatidylinositol dephosphorylation IGI
Inferred from Genetic Interaction
more info
 
Component Evidence Code Pubs
cellular bud membrane IDA
Inferred from Direct Assay
more info
PubMed 
cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT plasma membrane IDA
Inferred from Direct Assay
more info
 
Names
Ist2p
NP_009643.2
  • Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001134.8 

    Range
    420201..423041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178434.1NP_009643.2  Ist2p [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_009643.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P38250
    Conserved Domains (1) summary
    pfam04547
    Location:119587
    Blast Score: 500
    Anoctamin; Calcium-activated chloride channel