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    A1cf APOBEC1 complementation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170912, updated on 26-Jun-2015
    Official Symbol
    A1cfprovided by RGD
    Official Full Name
    APOBEC1 complementation factorprovided by RGD
    Primary source
    RGD:619834
    See related
    Ensembl:ENSRNOG00000033195
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acf; A1cft; Apobec-1
    Summary
    complementation factor that binds to RNA in a heterochromatin-associated protein complex that edits cytidine to uridine [RGD, Feb 2006]
    Orthologs
    See A1cf in MapViewer
    Location:
    1q52
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (250426021..250514245)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (257660187..257747893)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene protein kinase, cGMP-dependent, type 1 Neighboring gene uncharacterized LOC103691333 Neighboring gene uncharacterized LOC103691334 Neighboring gene uncharacterized LOC103691335 Neighboring gene N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 Neighboring gene sphingomyelin synthase 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    NOT double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    cytidine to uridine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytidine to uridine editing ISO
    Inferred from Sequence Orthology
    more info
     
    cytidine to uridine editing TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA localization resulting in posttranscriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA localization resulting in posttranscriptional regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    apolipoprotein B mRNA editing enzyme complex ISO
    Inferred from Sequence Orthology
    more info
     
    apolipoprotein B mRNA editing enzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA editing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    APOBEC1 complementation factor
    Names
    APOBEC1 complementation factor
    APOBEC1 complementation factort
    APOBEC1-stimulating protein
    Apobec-1 complementation factor APOBEC-1 stimulating protein
    Apobec-1 complementation factor, APOBEC-1 stimulating protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133400.1NP_596891.1  APOBEC1 complementation factor

      See identical proteins and their annotated locations for NP_596891.1

      Status: PROVISIONAL

      Source sequence(s)
      AF290984
      UniProtKB/Swiss-Prot
      Q923K9
      Conserved Domains (5) summary
      cd00048
      Location:442513
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd12486
      Location:55132
      RRM1_ACF; RNA recognition motif 1 found in vertebrate APOBEC-1 complementation factor (ACF)
      cd12498
      Location:223305
      RRM3_ACF; RNA recognition motif 3 in vertebrate APOBEC-1 complementation factor (ACF)
      TIGR01648
      Location:2586
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cl17169
      Location:134218
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      250426021..250514245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231272.2XP_006231334.1  

      UniProtKB/TrEMBL
      F1LNL0
      Related
      ENSRNOP00000062802, ENSRNOT00000067643
      Conserved Domains (5) summary
      TIGR01648
      Location:2594
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
      cd00048
      Location:450521
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd12486
      Location:55132
      RRM1_ACF; RNA recognition motif 1 found in vertebrate APOBEC-1 complementation factor (ACF)
      cd12498
      Location:223305
      RRM3_ACF; RNA recognition motif 3 in vertebrate APOBEC-1 complementation factor (ACF)
      cl17169
      Location:134218
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      226856680..226943695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)