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Pde4b phosphodiesterase 4B, cAMP specific [ Rattus norvegicus (Norway rat) ]

Gene ID: 24626, updated on 1-Feb-2015
Official Symbol
Pde4bprovided by RGD
Official Full Name
phosphodiesterase 4B, cAMP specificprovided by RGD
Primary source
RGD:3280
See related
Ensembl:ENSRNOG00000005905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Pde4B1; Pde4B2; Pde4B3; Pde4B4; PDE4/IVb
Summary
contains four isoforms expressed from the same gene; isoform Pde4b4 has cAMP specific phosphdiesterase activity and is inhibited by rolipram [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
See Pde4b in MapViewer
Location:
5q32
Exon count:
15
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (121759236..122136814)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (125623815..126001128)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene olfactory receptor pseudogene 1778 Neighboring gene PRAME family member 22-like Neighboring gene uncharacterized LOC103692427 Neighboring gene uncharacterized LOC102548249 Neighboring gene uncharacterized LOC102548308 Neighboring gene SH3-domain GRB2-like (endophilin) interacting protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC93193

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
3',5'-cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
cAMP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cAMP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
cAMP catabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
 
cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of relaxation of cardiac muscle ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
neutrophil homeostasis IEA
Inferred from Electronic Annotation
more info
 
neutrophil homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
NOT smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Z disc ISO
Inferred from Sequence Orthology
more info
 
cell periphery IEA
Inferred from Electronic Annotation
more info
 
cell periphery ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
3',5'-cyclic AMP phosphodiesterase
DPDE4
Phosphodiesterase 4B cAMP-specific (dunce
Phosphodiesterase 4B, cAMP-specific (dunce
NP_058727.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017031.2NP_058727.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4B

    See proteins identical to NP_058727.2

    Status: PROVISIONAL

    Source sequence(s)
    U95748
    UniProtKB/Swiss-Prot
    P14646
    Related
    ENSRNOP00000008278, ENSRNOT00000008278
    Conserved Domains (1) summary
    cd00077
    Location:390572
    HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

    Range
    121759236..122136814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 Alternate Rn_Celera

    Range
    115579422..115946626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)