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HOXA10 homeobox A10 [ Homo sapiens (human) ]

Gene ID: 3206, updated on 17-May-2015
Official Symbol
HOXA10provided by HGNC
Official Full Name
homeobox A10provided by HGNC
Primary source
HGNC:HGNC:5100
See related
Ensembl:ENSG00000253293; HPRD:00845; MIM:142957; Vega:OTTHUMG00000023436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PL; HOX1; HOX1H; HOX1.8
Summary
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
Orthologs
See HOXA10 in MapViewer
Location:
7p15.2
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (27170591..27180261, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (27210210..27219880, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HOXA10-HOXA9 readthrough Neighboring gene homeobox A9 Neighboring gene HOXA10 antisense RNA Neighboring gene microRNA 196b Neighboring gene homeobox A11 Neighboring gene HOXA11 antisense RNA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough HOXA10-HOXA9

Readthrough gene: HOXA10-HOXA9, Included gene: HOXA9

Homology

Clone Names

  • MGC12859

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
single fertilization IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
uterus development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
homeobox protein Hox-A10
Names
homeobox protein Hox-A10
homeo box A10
homeobox protein 1H
homeobox protein HOXA10
homeobox protein Hox-1.8
homeobox protein Hox-1H

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018951.3NP_061824.3  homeobox protein Hox-A10

    See identical proteins and their annotated locations for NP_061824.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BC013971, BF196481, BX439708
    Consensus CDS
    CCDS5410.2
    UniProtKB/Swiss-Prot
    P31260
    Related
    ENSP00000283921, OTTHUMP00000217273, ENST00000283921, OTTHUMT00000358724
    Conserved Domains (1) summary
    cd00086
    Location:337395
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RNA

  1. NR_037939.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AL710880, BC013971, BC071843, BF196481, DB267919

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    27170591..27180261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    27209927..27219601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153715.3: Suppressed sequence

    Description
    NM_153715.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.