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DRD4 dopamine receptor D4 [ Homo sapiens (human) ]

Gene ID: 1815, updated on 7-Dec-2014
Official Symbol
DRD4provided by HGNC
Official Full Name
dopamine receptor D4provided by HGNC
Primary source
HGNC:HGNC:3025
See related
Ensembl:ENSG00000069696; HPRD:00541; MIM:126452; Vega:OTTHUMG00000133312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D4DR
Summary
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
See DRD4 in Epigenomics, MapViewer
Location:
11p15.5
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (637305..640706)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (637305..640706)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cadherin-related family member 5 Neighboring gene secretin Neighboring gene DEAF1 transcription factor Neighboring gene transmembrane protein 80 Neighboring gene EPS8-like 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • Dopamine receptors, organism-specific biosystem (from REACTOME)
    Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Hypothetical Network for Drug Addiction, organism-specific biosystem (from WikiPathways)
    Hypothetical Network for Drug Addiction, organism-specific biosystemAdapted from figure 2 in [http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.0040002 Li et al.].
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
dopamine binding IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
Inferred from Direct Assay
more info
PubMed 
dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS
Inferred from Sequence or Structural Similarity
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
potassium channel regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
arachidonic acid secretion IDA
Inferred from Direct Assay
more info
PubMed 
behavioral fear response NAS
Non-traceable Author Statement
more info
PubMed 
behavioral response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
behavioral response to ethanol TAS
Traceable Author Statement
more info
PubMed 
cellular calcium ion homeostasis IC
Inferred by Curator
more info
PubMed 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
dopamine metabolic process IC
Inferred by Curator
more info
PubMed 
dopamine receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fear response ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
olfactory learning IEA
Inferred from Electronic Annotation
more info
 
photoperiodism IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine uptake involved in synaptic transmission IC
Inferred by Curator
more info
PubMed 
positive regulation of excitatory postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dopamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of inhibitory postsynaptic membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurotransmitter secretion IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine ISS
Inferred from Sequence or Structural Similarity
more info
 
response to histamine IDA
Inferred from Direct Assay
more info
PubMed 
response to steroid hormone IEA
Inferred from Electronic Annotation
more info
 
retina development in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
short-term memory IEA
Inferred from Electronic Annotation
more info
 
social behavior NAS
Non-traceable Author Statement
more info
PubMed 
synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
D(4) dopamine receptor
Names
D(4) dopamine receptor
dopamine D4 receptor
D(2C) dopamine receptor
seven transmembrane helix receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021241.1 

    Range
    5001..8402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000797.3NP_000788.2  D(4) dopamine receptor

    See proteins identical to NP_000788.2

    Status: REVIEWED

    Source sequence(s)
    AP006284, BM674709, EU432112, L12398
    Consensus CDS
    CCDS7710.1
    UniProtKB/Swiss-Prot
    P21917
    Related
    ENSP00000176183, OTTHUMP00000164435, ENST00000176183, OTTHUMT00000257109
    Conserved Domains (1) summary
    pfam00001
    Location:57400
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    637305..640706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 

    Range
    167178..170577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    636234..639634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    452513..456039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)