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RPS3 ribosomal protein S3 [ Homo sapiens (human) ]

Gene ID: 6188, updated on 17-Feb-2015
Official Symbol
RPS3provided by HGNC
Official Full Name
ribosomal protein S3provided by HGNC
Primary source
HGNC:HGNC:10420
See related
Ensembl:ENSG00000149273; HPRD:10941; MIM:600454; Vega:OTTHUMG00000165448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S3
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Orthologs
See RPS3 in MapViewer
Location:
11q13.3-q13.5
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (75399491..75422302)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (75110535..75133346)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene trophoblast glycoprotein-like Neighboring gene arrestin, beta 1 Neighboring gene microRNA 326 Neighboring gene small nucleolar RNA, C/D box 15A Neighboring gene small nucleolar RNA, C/D box 15B Neighboring gene kelch-like family member 35 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify ribosomal protein S3 (RPS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ26283, FLJ27450, MGC87870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-(apurinic or apyrimidinic site) lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
NF-kappaB binding IPI
Inferred from Physical Interaction
more info
PubMed 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
iron-sulfur cluster binding NAS
Non-traceable Author Statement
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidized purine nucleobase lesion DNA N-glycosylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA catabolic process, endonucleolytic IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA catabolic process, endonucleolytic IDA
Inferred from Direct Assay
more info
PubMed 
DNA catabolic process, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to DNA damage stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
 
gene expression TAS
Traceable Author Statement
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
positive regulation of DNA N-glycosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
translation IC
Inferred by Curator
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational elongation TAS
Traceable Author Statement
more info
 
translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
translational termination TAS
Traceable Author Statement
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with NF-kappaB complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
40S ribosomal protein S3
Names
40S ribosomal protein S3
IMR-90 ribosomal protein S3
NP_000996.2
NP_001243731.1
NP_001247435.1
NP_001247436.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005.4NP_000996.2  40S ribosomal protein S3 isoform 1

    See proteins identical to NP_000996.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 both encode the same protein (isoform 1).
    Source sequence(s)
    AP000744, BC034149, BM831460, CB241053
    Consensus CDS
    CCDS8236.1
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000434643, OTTHUMP00000229804, ENST00000531188, OTTHUMT00000384158
    Conserved Domains (3) summary
    cd02413
    Location:1595
    40S_S3_KH; K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3 is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH ...
    PTZ00084
    Location:4216
    PTZ00084; 40S ribosomal protein S3; Provisional
    pfam00189
    Location:104188
    Ribosomal_S3_C; Ribosomal protein S3, C-terminal domain
  2. NM_001256802.1NP_001243731.1  40S ribosomal protein S3 isoform 1

    See proteins identical to NP_001243731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1 and 2 both encode the same protein (isoform 1).
    Source sequence(s)
    AA976344, AW134501, BC034149, BM831460
    Consensus CDS
    CCDS8236.1
    UniProtKB/Swiss-Prot
    P23396
    Related
    ENSP00000436971, OTTHUMP00000229805, ENST00000527446, OTTHUMT00000384161
    Conserved Domains (3) summary
    cd02413
    Location:1595
    40S_S3_KH; K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3 is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH ...
    PTZ00084
    Location:4216
    PTZ00084; 40S ribosomal protein S3; Provisional
    pfam00189
    Location:104188
    Ribosomal_S3_C; Ribosomal protein S3, C-terminal domain
  3. NM_001260506.1NP_001247435.1  40S ribosomal protein S3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has two additional segments, one in the coding region and one in the 3' UTR, compared to variant 1. The resulting isoform (2) is longer and has an additional segment in the central region, compared to isoform 1.
    Source sequence(s)
    AP000744, BM831460, BM928330, BQ645330, CB241053, DW448503
    Consensus CDS
    CCDS58161.1
    UniProtKB/Swiss-Prot
    P23396
    Conserved Domains (3) summary
    cd02413
    Location:15111
    40S_S3_KH; K homology RNA-binding (KH) domain of the eukaryotic 40S small ribosomal subunit protein S3. S3 is part of the head region of the 40S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH ...
    PTZ00084
    Location:4232
    PTZ00084; 40S ribosomal protein S3; Provisional
    pfam00189
    Location:120204
    Ribosomal_S3_C; Ribosomal protein S3, C-terminal domain
  4. NM_001260507.1NP_001247436.1  40S ribosomal protein S3 isoform 3

    See proteins identical to NP_001247436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AP000744, BC013231, BE797417, BM831460, CB241053
    UniProtKB/Swiss-Prot
    P23396
    Conserved Domains (1) summary
    pfam00189
    Location:162
    Ribosomal_S3_C; Ribosomal protein S3, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38 Primary Assembly

    Range
    75399491..75422302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    74994110..75016921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 Alternate HuRef

    Range
    71407971..71430530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)