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SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 [ Homo sapiens (human) ]

Gene ID: 10568, updated on 13-Jan-2015
Official Symbol
SLC34A2provided by HGNC
Official Full Name
solute carrier family 34 (type II sodium/phosphate cotransporter), member 2provided by HGNC
Primary source
HGNC:HGNC:11020
See related
Ensembl:ENSG00000157765; HPRD:07251; MIM:604217; Vega:OTTHUMG00000097757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPTIIb; NAPI-3B; NAPI-IIb
Summary
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Orthologs
See SLC34A2 in MapViewer
Location:
4p15.2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (25655813..25678748)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (25656853..25680735)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929161 Neighboring gene uncharacterized LOC102723710 Neighboring gene S-phase kinase-associated protein 1 pseudogene Neighboring gene SRA stem-loop interacting RNA binding protein pseudogene Neighboring gene ribosomal protein S29 pseudogene 11

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Sodium-coupled phosphate cotransporters, organism-specific biosystem (from REACTOME)
    Sodium-coupled phosphate cotransporters, organism-specific biosystemPhosphorus is an essential element that is critical for structural and metabolic roles in all living organisms. Cells obtain phosphorus in the form of negatively-charged inorganic phosphate (Pi). Two...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
    Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...
  • Type II Na+/Pi cotransporters, organism-specific biosystem (from REACTOME)
    Type II Na+/Pi cotransporters, organism-specific biosystemThe SLC34 family of type II Na+/Pi cotransporters consist of three members; NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2) and NaPi-IIc (SLC34A3) (Murer H et al, 2004). They are expressed mainly in the kidne...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ90534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphate ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
sodium-dependent phosphate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
cellular phosphate ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
phosphate ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
phosphate ion transport IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEP
Inferred from Expression Pattern
more info
PubMed 
response to fructose IEA
Inferred from Electronic Annotation
more info
 
sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
sodium-dependent phosphate transport IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
sodium-dependent phosphate transport protein 2B
Names
sodium-dependent phosphate transport protein 2B
sodium/phosphate cotransporter 2B
type II sodium-dependent phosphate transporter 3b
solute carrier family 34 (sodium phosphate), member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021185.1 

    Range
    5001..27936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177998.1NP_001171469.1  sodium-dependent phosphate transport protein 2B isoform b

    See proteins identical to NP_001171469.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436, AK314514, CN479082, DB201517
    Consensus CDS
    CCDS54750.1
    UniProtKB/Swiss-Prot
    O95436
    Conserved Domains (2) summary
    TIGR01013
    Location:104603
    2a58; Phosphate:Na+ Symporter (PNaS) Family
    pfam02690
    Location:378503
    Na_Pi_cotrans; Na+/Pi-cotransporter
  2. NM_001177999.1NP_001171470.1  sodium-dependent phosphate transport protein 2B isoform b

    See proteins identical to NP_001171470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC092436, AK314514, CN479082, DB241180
    Consensus CDS
    CCDS54750.1
    UniProtKB/Swiss-Prot
    O95436
    Conserved Domains (2) summary
    TIGR01013
    Location:104603
    2a58; Phosphate:Na+ Symporter (PNaS) Family
    pfam02690
    Location:378503
    Na_Pi_cotrans; Na+/Pi-cotransporter
  3. NM_006424.2NP_006415.2  sodium-dependent phosphate transport protein 2B isoform a

    See proteins identical to NP_006415.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC092436, AF111856, CA435368, DB201517
    Consensus CDS
    CCDS3435.1
    UniProtKB/Swiss-Prot
    O95436
    Related
    ENSP00000371483, OTTHUMP00000123386, ENST00000382051, OTTHUMT00000214990
    Conserved Domains (2) summary
    TIGR01013
    Location:105604
    2a58; Phosphate:Na+ Symporter (PNaS) Family
    pfam02690
    Location:379504
    Na_Pi_cotrans; Na+/Pi-cotransporter

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    25655813..25678748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    25657246..25680195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    24995885..25018820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)