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Cdkn1a cyclin-dependent kinase inhibitor 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 114851, updated on 17-Feb-2015
Official Symbol
Cdkn1aprovided by RGD
Official Full Name
cyclin-dependent kinase inhibitor 1Aprovided by RGD
Primary source
RGD:69328
See related
Ensembl:ENSRNOG00000000521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Cip1; UV96; Waf1
Summary
a Cdk inhibitor; involved in negative regulation of the cell cycle [RGD, Feb 2006]
Orthologs
See Cdkn1a in MapViewer
Location:
20p12
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (6348422..6358864)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (8592437..8602879)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 Neighboring gene serine/arginine-rich splicing factor 3 Neighboring gene RAB44, member RAS oncogene family Neighboring gene allatostatin-A receptor-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cyclin binding IEA
Inferred from Electronic Annotation
more info
 
cyclin binding ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase activating kinase activity IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein kinase activating kinase activity ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to ionizing radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
cellular senescence IEA
Inferred from Electronic Annotation
more info
 
cellular senescence ISO
Inferred from Sequence Orthology
more info
 
intestinal epithelial cell maturation IEP
Inferred from Expression Pattern
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
mitotic cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
organ regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of protein import into nucleus, translocation IEA
Inferred from Electronic Annotation
more info
 
regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
response to UV IEA
Inferred from Electronic Annotation
more info
 
response to UV ISO
Inferred from Sequence Orthology
more info
 
response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to corticosterone IEP
Inferred from Expression Pattern
more info
PubMed 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to hyperoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
PubMed 
response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
PCNA-p21 complex IEA
Inferred from Electronic Annotation
more info
 
PCNA-p21 complex ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cyclin-dependent kinase inhibitor 1
Names
cyclin-dependent kinase inhibitor 1
cyclin-dependent kinase inhibitor 1A (P21)
cyclin-dependent kinase inhibitor 1A (p21, Cip1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080782.3NP_542960.1  cyclin-dependent kinase inhibitor 1

    See proteins identical to NP_542960.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100620
    UniProtKB/TrEMBL
    Q64315
    Related
    ENSRNOP00000000628, ENSRNOT00000000628
    Conserved Domains (1) summary
    pfam02234
    Location:1868
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

    Range
    6348422..6358864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256128.2XP_006256190.1  

    See proteins identical to XP_006256190.1

    UniProtKB/TrEMBL
    Q64315
    Conserved Domains (1) summary
    pfam02234
    Location:1868
    CDI; Cyclin-dependent kinase inhibitor

Alternate Rn_Celera

Genomic

  1. AC_000088.1 Alternate Rn_Celera

    Range
    8699290..8709718
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)