Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Cxcl10 chemokine (C-X-C motif) ligand 10 [ Mus musculus (house mouse) ]

    Gene ID: 15945, updated on 24-Jun-2016
    Official Symbol
    Cxcl10provided by MGI
    Official Full Name
    chemokine (C-X-C motif) ligand 10provided by MGI
    Primary source
    MGI:MGI:1352450
    See related
    Ensembl:ENSMUSG00000034855 Vega:OTTMUSG00000028740
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
    Orthologs
    Location:
    5 E2; 5 46.57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (92346638..92348889, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (92775667..92777880, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene chemokine (C-X-C motif) ligand 9 Neighboring gene ADP-ribosyltransferase 3 Neighboring gene chemokine (C-X-C motif) ligand 11 Neighboring gene CWF19-like 1, cell cycle control pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    CXCR chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    CXCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chemokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chemokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of T cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    C-X-C motif chemokine 10
    Names
    10 kDa interferon gamma-induced protein
    gamma-IP10
    interferon activated gene 10
    interferon-gamma induced protein CRG-2
    interferon-gamma-induced protein CRG-2
    small inducible cytokine B subfamily (Cys-X-Cys), member 10
    small-inducible cytokine B10

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021274.2NP_067249.1  C-X-C motif chemokine 10 precursor

      See identical proteins and their annotated locations for NP_067249.1

      Status: VALIDATED

      Source sequence(s)
      BC030067, BY165450
      Consensus CDS
      CCDS39153.1
      UniProtKB/Swiss-Prot
      P17515
      UniProtKB/TrEMBL
      Q548V9
      Related
      ENSMUSP00000047646, OTTMUSP00000036424, ENSMUST00000038816, OTTMUST00000071189
      Conserved Domains (1) summary
      cd00273
      Location:2788
      Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      92346638..92348889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)