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Ptgs2 prostaglandin-endoperoxide synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 19225, updated on 22-Dec-2014
Official Symbol
Ptgs2provided by MGI
Official Full Name
prostaglandin-endoperoxide synthase 2provided by MGI
Primary source
MGI:MGI:97798
See related
Ensembl:ENSMUSG00000032487; Vega:OTTMUSG00000049547
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2
See Ptgs2 in Epigenomics, MapViewer
Location:
1 H1; 1 63.84 cM
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (150100124..150108017)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand Neighboring gene prostaglandin-endoperoxide synthase 2, opposite strand 2 Neighboring gene predicted gene 15453

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
heme binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ISO
Inferred from Sequence Orthology
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
prostaglandin-endoperoxide synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-endoperoxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
anagen IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
bone mineralization ISO
Inferred from Sequence Orthology
more info
PubMed 
brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclooxygenase pathway IDA
Inferred from Direct Assay
more info
PubMed 
cyclooxygenase pathway ISO
Inferred from Sequence Orthology
more info
 
decidualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
decidualization ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryo implantation ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation NAS
Non-traceable Author Statement
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
ovulation ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fever generation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fever generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast growth factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of platelet-derived growth factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
positive regulation vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to cytokine ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
PubMed 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prostaglandin G/H synthase 2
Names
prostaglandin G/H synthase 2
PES-2
PHS II
gripghs
PGH synthase 2
cyclooxygenase 2
cyclooxygenase-2
prostaglandin H2 synthase 2
glucocorticoid-regulated inflammatory cyclooxygenase
macrophage activation-associated marker protein P71/73
NP_035328.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011198.3NP_035328.2  prostaglandin G/H synthase 2 precursor

    See proteins identical to NP_035328.2

    Status: PROVISIONAL

    Source sequence(s)
    AC114655
    Consensus CDS
    CCDS15353.1
    UniProtKB/Swiss-Prot
    Q05769
    Related
    ENSMUSP00000035065, OTTMUSP00000068320, ENSMUST00000035065, OTTMUST00000126288
    Conserved Domains (3) summary
    cd09816
    Location:75562
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:1955
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam03098
    Location:122568
    An_peroxidase; Animal haem peroxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    150100124..150108017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    152546728..152554611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)