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Ireb2 iron responsive element binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 64602, updated on 24-Jan-2015
Official Symbol
Ireb2provided by MGI
Official Full Name
iron responsive element binding protein 2provided by MGI
Primary source
MGI:MGI:1928268
See related
Ensembl:ENSMUSG00000032293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Irp2; D9Ertd85e
Orthologs
See Ireb2 in MapViewer
Location:
9 B; 9 29.81 cM
Exon count:
23
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (54863665..54912534)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene RAB7, member RAS oncogene family, pseudogene 1 Neighboring gene predicted gene, 30935 Neighboring gene hydroxylysine kinase 1 Neighboring gene cDNA sequence AY074887 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Iron Homeostasis, organism-specific biosystem (from WikiPathways)
    Iron Homeostasis, organism-specific biosystemIron is nessisary for all mammalian cells but is also toxic in excess. This pathway shows the regulation of iron between a cell and the blood stream.

Markers

Homology

Clone Names

  • DKFZp564D1164

Gene Ontology Provided by MGI

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding ISO
Inferred from Sequence Orthology
more info
 
iron-responsive element binding IDA
Inferred from Direct Assay
more info
PubMed 
iron-responsive element binding ISO
Inferred from Sequence Orthology
more info
 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
translation repressor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
iron ion transport IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of translation TAS
Traceable Author Statement
more info
PubMed 
post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
protoporphyrinogen IX biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
iron-responsive element-binding protein 2
Names
iron-responsive element-binding protein 2
IRE-BP 2
iron regulatory protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022655.3NP_073146.2  iron-responsive element-binding protein 2

    See proteins identical to NP_073146.2

    Status: VALIDATED

    Source sequence(s)
    AC161264, CJ093933, CK636500, CN534597, CN664620, CO431396, CV558274
    Consensus CDS
    CCDS23196.1
    UniProtKB/Swiss-Prot
    Q811J3
    Related
    ENSMUSP00000034843, ENSMUST00000034843
    Conserved Domains (3) summary
    cd01586
    Location:85641
    AcnA_IRP; Aconitase A catalytic domain
    cd01580
    Location:745913
    AcnA_IRP_Swivel; Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group ...
    PTZ00092
    Location:3961
    PTZ00092; aconitate hydratase-like protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    54863665..54912534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511335.1XP_006511398.1  

    Conserved Domains (1) summary
    cd01586
    Location:85641
    AcnA_IRP; Aconitase A catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    52108353..52158699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)