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    ITK IL2 inducible T-cell kinase [ Homo sapiens (human) ]

    Gene ID: 3702, updated on 7-Feb-2016
    Official Symbol
    ITKprovided by HGNC
    Official Full Name
    IL2 inducible T-cell kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:6171
    See related
    Ensembl:ENSG00000113263; HPRD:01746; MIM:186973; Vega:OTTHUMG00000130245
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMT; LYK; LPFS1; PSCTK2
    Summary
    This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q31-q32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (157180896..157255099)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (156607907..156682109)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 7 Neighboring gene family with sequence similarity 71 member B Neighboring gene cytoplasmic FMR1 interacting protein 2 Neighboring gene uncharacterized LOC102724404 Neighboring gene fibronectin type III domain containing 9 Neighboring gene ribosomal protein L26 pseudogene 18

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Lymphoproliferative syndrome 1
    MedGen: C2751686 OMIM: 613011 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of personality traits in bipolar patients.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Inducible T-cell kinase (ITK) affects viral entry and gp120-induced actin reorganization, but does not affect HIV-1 reverse transcription or proviral DNA integration PubMed
    Nef nef HIV-1 Nef alleles from representative M-group HIV-1 subtypes can interact with ITK. Selective ITK inhibitor blocks HIV-1 infectivity and replication in a Nef-dependent manner PubMed
    nef A cell-based bimolecular fluorescence complementation assay demonstrates that HIV-1 Nef interacts with the Tec family members Bmx, Btk, and Itk, but not with Tec or Txk in 293T cells PubMed
    Pr55(Gag) gag Tec kinase chemical inhibitors diminish the recruitment of ITK to the plasma membrane perturbing HIV-1 Gag-ITK co-localization, disrupting F-actin polymerization, and inhibiting HIV-1 release and replication PubMed
    gag HIV-1 Gag, ITK, and F-actin are located in overlapping and discrete regions of T cell-T cell contact sites PubMed
    gag HIV-1 Gag and ITK are present at regions that contain cholera toxin B in HIV-1 infected T cells, indicating that Gag and ITK co-localize in lipid raft microdomains PubMed
    gag HIV-1 Gag co-localizes with IL2-inducible T-cell kinase (ITK) at the plasma membrane of transfected HEK293T cells and HIV-1 infected T cells PubMed
    gag ITK is required for efficient transcription from the HIV-1 LTR, induces a modest increase in Gag expression, and enhances virion production PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Class I PI3K signaling events, organism-specific biosystem
      Class I PI3K signaling events
    • FCERI mediated Ca+2 mobilization, organism-specific biosystem (from REACTOME)
      FCERI mediated Ca+2 mobilization, organism-specific biosystemIncrease of intracellular calcium in mast cells is most crucial for mast cell degranulation. Elevation of intracellular calcium is achieved by activation of PLC-gamma. Mast cells express both PLC-gam...
    • Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
      Fc epsilon receptor (FCERI) signaling, organism-specific biosystemMast cells (MC) are distributed in tissues throughout the human body and have long been recognized as key cells of type I hypersensitivity reactions. They also play important roles in inflammatory an...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Generation of second messenger molecules, organism-specific biosystem (from REACTOME)
      Generation of second messenger molecules, organism-specific biosystemIn addition to serving as a scaffold via auto-phosphorylation, ZAP-70 also phosphorylates a restricted set of substrates following TCR stimulation - including LAT and SLP-76. These substrates have be...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
      Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • Leukocyte transendothelial migration, conserved biosystem (from KEGG)
      Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • TCR signaling, organism-specific biosystem (from REACTOME)
      TCR signaling, organism-specific biosystemThe TCR is a multisubunit complex that consists of clonotypic alpha/beta chains noncovalently associated with the invariant CD3 delta/epsilon/gamma and TCR zeta chains. T cell activation by antigen p...
    • TCR signaling in naive CD4+ T cells, organism-specific biosystem (from Pathway Interaction Database)
      TCR signaling in naive CD4+ T cells, organism-specific biosystem
      TCR signaling in naive CD4+ T cells
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC126257, MGC126258

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    Fc-epsilon receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    NK T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    T cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    activation of phospholipase C activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    adaptive immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
     
    interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    tyrosine-protein kinase ITK/TSK
    Names
    IL-2-inducible T cell kinase
    IL-2-inducible T-cell kinase
    IL2-inducible T-cell kinase
    T-cell-specific kinase
    homolog of mouse T-cell itk/tsk
    interleukin-2-inducible T cell kinase
    interleukin-2-inducible T-cell kinase
    kinase EMT
    tyrosine-protein kinase LYK
    NP_005537.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016276.1 RefSeqGene

      Range
      5001..79203
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_189

    mRNA and Protein(s)

    1. NM_005546.3NP_005537.3  tyrosine-protein kinase ITK/TSK

      See identical proteins and their annotated locations for NP_005537.3

      Status: REVIEWED

      Source sequence(s)
      D13720
      Consensus CDS
      CCDS4336.1
      UniProtKB/Swiss-Prot
      Q08881
      Related
      ENSP00000398655, OTTHUMP00000160737, ENST00000422843, OTTHUMT00000252569
      Conserved Domains (5) summary
      cd05112
      Location:358613
      PTKc_Itk; Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase
      cd10396
      Location:232340
      SH2_Tec_Itk; Src homology 2 (SH2) domain found in Tec protein, IL2-inducible T-cell kinase (Itk)
      cd11908
      Location:174229
      SH3_ITK; Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase
      pfam07714
      Location:363612
      Pkinase_Tyr; Protein tyrosine kinase
      cd01238
      Location:7148
      PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

      Range
      157180896..157255099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      156040619..156114765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)