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    NSL1 protein necrotic spotted lesions 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839735, updated on 8-Jan-2015
    Gene symbol
    NSL1
    Gene description
    protein necrotic spotted lesions 1
    Primary source
    TAIR:AT1G28380
    Locus tag
    AT1G28380
    Gene type
    protein coding
    RNA name
    protein necrotic spotted lesions 1
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3M18.18; F3M18_18; necrotic spotted lesions 1; NSL1
    Summary
    This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.
    See NSL1 in MapViewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (9963593..9966320)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ethylene-responsive transcription factor 11 Neighboring gene hypothetical protein Neighboring gene serine/threonine-protein kinase-like protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NM_102605.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    ER to Golgi vesicle-mediated transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    ER-nucleus signaling pathway RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    MAPK cascade RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    amino acid import RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    ammonium transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    anion transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    basic amino acid transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response by callose deposition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response by callose deposition RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    defense response to bacterium RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    defense response to fungus RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    detection of biotic stimulus RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    jasmonic acid mediated signaling pathway RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    membrane fusion RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    negative regulation of defense response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    negative regulation of programmed cell death RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    nucleotide transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein targeting to membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of defense response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of hydrogen peroxide metabolic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of ion transport RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of multi-organism process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of plant-type hypersensitive response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    regulation of salicylic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory burst involved in defense response RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    response to chitin RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    response to endoplasmic reticulum stress RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    response to other organism RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    response to salt stress TAS
    Traceable Author Statement
    more info
    PubMed 
    salicylic acid biosynthetic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    salicylic acid mediated signaling pathway RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    systemic acquired resistance RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    systemic acquired resistance, salicylic acid mediated signaling pathway RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    cell RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    cytoplasm RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    nucleus ISM
    Inferred from Sequence Model
    more info
     
    Names
    protein necrotic spotted lesions 1
    NP_564307.1
    • necrotic spotted lesions 1 (NSL1); CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain (InterPro:IPR020864); BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein (TAIR:AT4G24290.2); Has 203 Blast hits to 202 proteins in 18 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 202; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      9963593..9966320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102605.2NP_564307.1  protein necrotic spotted lesions 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SGN6
      Conserved Domains (1) summary
      pfam01823
      Location:109324
      MACPF; MAC/Perforin domain