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CASP5 caspase 5, apoptosis-related cysteine peptidase [ Homo sapiens (human) ]

Gene ID: 838, updated on 8-Feb-2015
Official Symbol
CASP5provided by HGNC
Official Full Name
caspase 5, apoptosis-related cysteine peptidaseprovided by HGNC
Primary source
HGNC:HGNC:1506
See related
Ensembl:ENSG00000137757; HPRD:04048; MIM:602665; Vega:OTTHUMG00000048073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICH-3; ICEREL-III; ICE(rel)III
Summary
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
Orthologs
See CASP5 in MapViewer
Location:
11q22.2-q22.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (104994240..105023168, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (104864967..104893895, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene caspase 4, apoptosis-related cysteine peptidase pseudogene Neighboring gene caspase 4, apoptosis-related cysteine peptidase Neighboring gene caspase 1, apoptosis-related cysteine peptidase Neighboring gene caspase recruitment domain family, member 16

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • NOD pathway, organism-specific biosystem (from WikiPathways)
    NOD pathway, organism-specific biosystemThe NOD (nucleotide-binding oligomerization domain) proteins NOD1 and NOD2 have important roles in innate immunity as sensors of microbial components derived from bacterial peptidoglycan. The importa...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC141966

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
cysteine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
scaffold protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of interleukin-1 beta secretion IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
pyroptosis IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
substantia nigra development IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
NOT AIM2 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT IPAF inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
NLRP1 inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT NLRP3 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
caspase-5
Names
caspase-5
CASP-5
ICE(rel)-III
TY protease
caspase 5, apoptosis-related cysteine protease
protease ICH-3
protease TY
NP_001129581.1
NP_001129582.1
NP_001129584.1
NP_004338.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136109.1NP_001129581.1  caspase-5 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) is lacking an in-frame coding exon compared to transcript variant a, resulting in a shorter isoform (b) missing a 58 aa protein segment compared to isoform a.
    Source sequence(s)
    AK296660, DQ228673, DR005081, X94993
    Consensus CDS
    CCDS44719.1
    UniProtKB/Swiss-Prot
    P51878
    Related
    ENSP00000388365, OTTHUMP00000209889, ENST00000444749, OTTHUMT00000344191
    Conserved Domains (2) summary
    cd00032
    Location:124373
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:584
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_001136110.1NP_001129582.1  caspase-5 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) is lacking two consecutive in-frame coding exons compared to transcript variant a, resulting in a shorter isoform (c) missing a 142 aa protein segment compared to isoform a.
    Source sequence(s)
    AK296660, DQ228674, X94993
    Consensus CDS
    CCDS44718.1
    UniProtKB/Swiss-Prot
    P51878
    Related
    ENSP00000398130, ENST00000418434
    Conserved Domains (1) summary
    cd00032
    Location:40289
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
  3. NM_001136112.1NP_001129584.1  caspase-5 isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) uses an in-frame, alternate acceptor splice site at an internal coding exon compared to transcript variant a, resulting in a longer isoform (f) containing an additional 13 aa protein segment compared to isoform a.
    Source sequence(s)
    AK296660, DQ228677, DR005081, X94993
    Consensus CDS
    CCDS44720.1
    UniProtKB/Swiss-Prot
    P51878
    Related
    ENSP00000376849, ENST00000393141
    Conserved Domains (2) summary
    cd00032
    Location:195444
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:76155
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. NM_004347.3NP_004338.3  caspase-5 isoform a precursor

    See proteins identical to NP_004338.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) encodes isoform a.
    Source sequence(s)
    AK296660, DQ228672, DR005081, X94993
    Consensus CDS
    CCDS8328.2
    UniProtKB/Swiss-Prot
    P51878
    Related
    ENSP00000260315, OTTHUMP00000045729, ENST00000260315, OTTHUMT00000109397
    Conserved Domains (2) summary
    cd00032
    Location:182431
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:63142
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. NR_024239.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) is missing two internal coding exons compared to transcript variant a. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). There is a publication (PMID:16893518) reporting the expression of this transcript, hence it is represented as a variant RefSeq, however, the predicted protein is not represented because it is significantly truncated.
    Source sequence(s)
    AK296660, DQ228676, DR005081, X94993
  2. NR_036562.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) lacks three alternate internal exons, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296660, DQ228675, X94993

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38 Primary Assembly

    Range
    104994240..105023168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718925.1XP_006718988.1  

    Conserved Domains (2) summary
    cl00042
    Location:167301
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:47126
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    104747902..104776824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 Alternate HuRef

    Range
    100795913..100824883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)