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Tlr2 toll-like receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 24088, updated on 21-Jul-2014
Official Symbol
Tlr2provided by MGI
Official Full Name
toll-like receptor 2provided by MGI
Primary source
MGI:1346060
See related
Ensembl:ENSMUSG00000027995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly105
See Tlr2 in Epigenomics, MapViewer
Location:
3 E3; 3
Exon count :
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (83836272..83841816, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene secreted frizzled-related protein 2 Neighboring gene ring finger protein 175 pseudogene Neighboring gene RIKEN cDNA D930015E06 gene Neighboring gene uncharacterized LOC102632212

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Hepatitis B, organism-specific biosystem (from KEGG)
    Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
  • Herpes simplex infection, organism-specific biosystem (from KEGG)
    Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Herpes simplex infection, conserved biosystem (from KEGG)
    Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
    Toll Like Receptor signaling, organism-specific biosystem
    Toll Like Receptor signaling
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
diacyl lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipopeptide binding ISO
Inferred from Sequence Orthology
more info
 
lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
signaling pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
triacyl lipopeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
triacyl lipopeptide binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
MyD88-dependent toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
cell surface pattern recognition receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to bacterial lipopeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to bacterial lipopeptide TAS
Traceable Author Statement
more info
PubMed 
cellular response to diacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipoteichoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lipoteichoic acid ISO
Inferred from Sequence Orthology
more info
 
cellular response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
central nervous system myelin formation ISO
Inferred from Sequence Orthology
more info
 
chloramphenicol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
detection of diacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
detection of triacyl bacterial lipopeptide ISO
Inferred from Sequence Orthology
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
induction by symbiont of defense-related host nitric oxide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
 
microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of growth of symbiont in host IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-17 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
nitric oxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-18 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
response to bacterial lipoprotein ISO
Inferred from Sequence Orthology
more info
 
response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to fatty acid ISO
Inferred from Sequence Orthology
more info
 
response to molecule of bacterial origin IEA
Inferred from Electronic Annotation
more info
 
response to molecule of fungal origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Toll-like receptor 1-Toll-like receptor 2 protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Toll-like receptor 2-Toll-like receptor 6 protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
cell body ISO
Inferred from Sequence Orthology
more info
 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
toll-like receptor 2
Names
toll-like receptor 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011905.3NP_036035.3  toll-like receptor 2 precursor

    See proteins identical to NP_036035.3

    Status: VALIDATED

    Source sequence(s)
    AK005043, BP771904, BY743020
    Consensus CDS
    CCDS17435.1
    UniProtKB/TrEMBL
    G3X8Y8
    UniProtKB/Swiss-Prot
    Q9QUN7
    Related
    ENSMUSP00000029623, ENSMUST00000029623
    Conserved Domains (4) summary
    smart00082
    Location:533586
    Blast Score: 93
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:640784
    Blast Score: 358
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:55151
    Blast Score: 95
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:77135
    Blast Score: 153
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    83836272..83841816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501460.1XP_006501523.1  

    Conserved Domains (4) summary
    smart00082
    Location:543596
    Blast Score: 93
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:650794
    Blast Score: 358
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:65161
    Blast Score: 95
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam13855
    Location:87145
    Blast Score: 154
    LRR_8; Leucine rich repeat

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    83852064..83857400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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