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    TPP2 tripeptidyl peptidase 2 [ Homo sapiens (human) ]

    Gene ID: 7174, updated on 8-Aug-2016
    Official Symbol
    TPP2provided by HGNC
    Official Full Name
    tripeptidyl peptidase 2provided by HGNC
    Primary source
    HGNC:HGNC:12016
    See related
    Ensembl:ENSG00000134900 HPRD:01834; MIM:190470; Vega:OTTHUMG00000017305
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TPP-2; TPPII
    Summary
    This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    13q32-q33
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (102596936..102679174)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (103249286..103331524)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 14 Neighboring gene FGF14 antisense RNA 2 Neighboring gene uncharacterized LOC107984588 Neighboring gene methyltransferase like 21C Neighboring gene coiled-coil domain containing 168

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ40359

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aminopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    endopeptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    tripeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    protein polyubiquitination TAS
    Traceable Author Statement
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    tripeptidyl-peptidase 2
    Names
    TPP-II
    tripeptidyl aminopeptidase
    tripeptidyl peptidase II
    tripeptidyl-peptidase II
    NP_003282.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003291.2NP_003282.2  tripeptidyl-peptidase 2

      See identical proteins and their annotated locations for NP_003282.2

      Status: REVIEWED

      Source sequence(s)
      AU132468, BC039905, BI492495, M55169, M73047
      Consensus CDS
      CCDS9502.1
      UniProtKB/Swiss-Prot
      P29144
      Related
      ENSP00000365233, OTTHUMP00000018664, ENST00000376065, OTTHUMT00000045683
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:243502
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778965
      TPPII; Tripeptidyl peptidase II

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      102596936..102679174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254070.1XP_005254127.1  

      See identical proteins and their annotated locations for XP_005254127.1

      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:243502
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778965
      TPPII; Tripeptidyl peptidase II
    2. XM_005254072.1XP_005254129.1  

      See identical proteins and their annotated locations for XP_005254129.1

      UniProtKB/TrEMBL
      Q5VZU9
      Related
      ENSP00000365220, OTTHUMP00000018665, ENST00000376052, OTTHUMT00000045684
      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:243502
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778965
      TPPII; Tripeptidyl peptidase II
    3. XM_005254071.1XP_005254128.1  

      See identical proteins and their annotated locations for XP_005254128.1

      Conserved Domains (3) summary
      cd04857
      Location:14489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:243502
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778965
      TPPII; Tripeptidyl peptidase II

    RNA

    1. XR_001749654.1 RNA Sequence

    2. XR_243046.1 RNA Sequence

    3. XR_001749655.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      103218763..103300981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)