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Pdgfb platelet derived growth factor, B polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18591, updated on 20-Feb-2015
Official Symbol
Pdgfbprovided by MGI
Official Full Name
platelet derived growth factor, B polypeptideprovided by MGI
Primary source
MGI:MGI:97528
See related
Ensembl:ENSMUSG00000000489
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sis; PDGF-B
Orthologs
See Pdgfb in MapViewer
Location:
15 37.85 cM; 15 E
Exon count:
8
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (79995865..80014808, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene chromobox 7 Neighboring gene microRNA 7213 Neighboring gene predicted gene, 31044 Neighboring gene uncharacterized LOC105245994

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
superoxide-generating NADPH oxidase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
 
blood vessel morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell projection assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to mycophenolic acid ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell proliferation involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric glomerular mesangial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric glomerular mesangial cell proliferation involved in metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasodilation TAS
Traceable Author Statement
more info
PubMed 
paracrine signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glomerular filtration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric mesenchymal cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vasoconstriction TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
substrate-dependent cell migration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
platelet-derived growth factor subunit B
Names
platelet-derived growth factor subunit B
PDGF subunit B
PDGF-2
c-sis
platelet-derived growth factor B chain
platelet-derived growth factor beta polypeptide
proto-oncogene c-Sis

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011057.3NP_035187.2  platelet-derived growth factor subunit B precursor

    See proteins identical to NP_035187.2

    Status: PROVISIONAL

    Source sequence(s)
    BC053430
    Consensus CDS
    CCDS27656.1
    UniProtKB/Swiss-Prot
    P31240
    Related
    ENSMUSP00000000500, ENSMUST00000000500
    Conserved Domains (2) summary
    cd00135
    Location:95182
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    pfam04692
    Location:2196
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    79995865..80014808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520592.2XP_006520655.1  

    Conserved Domains (1) summary
    cd00135
    Location:32119
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    82118150..82136874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)