Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    SCN5A sodium voltage-gated channel alpha subunit 5 [ Homo sapiens (human) ]

    Gene ID: 6331, updated on 1-May-2016
    Official Symbol
    SCN5Aprovided by HGNC
    Official Full Name
    sodium voltage-gated channel alpha subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:10593
    See related
    Ensembl:ENSG00000183873 HPRD:02543; MIM:600163; Vega:OTTHUMG00000156166
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB1; HB2; HH1; IVF; VF1; HBBD; ICCD; LQT3; SSS1; CDCD2; CMD1E; CMPD2; PFHB1; Nav1.5
    Summary
    The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3p21
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (38548058..38649673, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38589553..38691164, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene endo/exonuclease (5'-3'), endonuclease G-like Neighboring gene ribosomal protein L18a pseudogene 7 Neighboring gene sodium voltage-gated channel alpha subunit 10 Neighboring gene uncharacterized LOC105377034

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Professional guidelines

    Description
    Professional guideline
    ACMG 2013

    The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in SCN5A that are pathogenic or expected to be pathogenic.

    GuidelinePubMed

    Associated conditions

    Description Tests
    Atrial fibrillation, familial, 10
    MedGen: C3151464 OMIM: 614022 GeneReviews: Not available
    Compare labs
    Brugada syndrome 1
    MedGen: CN029323 OMIM: 601144 GeneReviews: Brugada Syndrome
    Compare labs
    Dilated cardiomyopathy 1E Compare labs
    Long QT syndrome 3
    MedGen: C1859062 OMIM: 603830 GeneReviews: Long QT Syndrome
    Compare labs
    Paroxysmal familial ventricular fibrillation
    MedGen: C0340493 OMIM: 603829 GeneReviews: Not available
    Compare labs
    Progressive familial heart block type 1A
    MedGen: C1879286 OMIM: 113900 GeneReviews: Not available
    Compare labs
    Sick sinus syndrome 1, autosomal recessive
    MedGen: C1837845 OMIM: 608567 GeneReviews: Not available
    Compare labs
    Sudden infant death syndrome
    MedGen: C0038644 OMIM: 272120 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2016-01-14)

    ClinGen Genome Curation Page
    Haploinsufficency

    Some evidence for dosage pathogenicity (Last evaluated (2016-01-14)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.
    NHGRI GWA Catalog
    Common variants at ten loci influence QT interval duration in the QTGEN Study.
    NHGRI GWA Catalog
    Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
    NHGRI GWA Catalog
    Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction.
    NHGRI GWA Catalog
    Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.
    NHGRI GWA Catalog
    Genetic determinants of P wave duration and PR segment.
    NHGRI GWA Catalog
    Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk.
    NHGRI GWA Catalog
    Genome-wide association studies of the PR interval in African Americans.
    NHGRI GWA Catalog
    Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
    NHGRI GWA Catalog
    Genome-wide association study of PR interval.
    NHGRI GWA Catalog
    Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.
    NHGRI GWA Catalog
    Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
    NHGRI GWA Catalog
    Several common variants modulate heart rate, PR interval and QRS duration.
    NHGRI GWA Catalog
    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cardiac Progenitor Differentiation, organism-specific biosystem (from WikiPathways)
      Cardiac Progenitor Differentiation, organism-specific biosystemFactors involved in the induction of cardiac differentiation in vitro and in vivo. This model was based on the below two review articles.
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
      Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Phase 0 - rapid depolarisation, organism-specific biosystem (from REACTOME)
      Phase 0 - rapid depolarisation, organism-specific biosystemPhase 0 is the rapid depolarisation phase in which electrical stimulation of a cell initiates events involving the influx and efflux of ions resulting in the production of a cell's action potential. ...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ankyrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nitric-oxide synthase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    voltage-gated sodium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel activity involved in AV node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated sodium channel activity involved in Purkinje myocyte action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated sodium channel activity involved in SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated sodium channel activity involved in bundle of His cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    voltage-gated sodium channel activity involved in cardiac muscle cell action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    AV node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    AV node cell to bundle of His cell communication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brainstem development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bundle of His cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac conduction TAS
    Traceable Author Statement
    more info
     
    cardiac muscle cell action potential involved in contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac ventricle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebellum development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    membrane depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane depolarization during AV node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization during Purkinje myocyte cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization during SA node cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization during action potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane depolarization during bundle of His cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization during cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    odontogenesis of dentin-containing tooth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of action potential ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of atrial cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of atrial cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate by cardiac conduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ventricular cardiac muscle cell membrane repolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to denervation involved in regulation of muscle adaptation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sodium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    telencephalon development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    T-tubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with caveola TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    voltage-gated sodium channel complex IC
    Inferred by Curator
    more info
    PubMed 
    voltage-gated sodium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    sodium channel protein type 5 subunit alpha
    Names
    cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit
    sodium channel protein cardiac muscle subunit alpha
    sodium channel, voltage gated, type V alpha subunit
    sodium channel, voltage-gated, type V, alpha subunit
    voltage-gated sodium channel subunit alpha Nav1.5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008934.1 RefSeqGene

      Range
      5000..106611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_289

    mRNA and Protein(s)

    1. NM_000335.4NP_000326.2  sodium channel protein type 5 subunit alpha isoform b

      See identical proteins and their annotated locations for NP_000326.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different acceptor splice site at one of the coding exons, 3 nt downstream of that used by transcript variant 1. This results in an isoform (b) shorter by just a single aa, compared to isoform a.
      Source sequence(s)
      AB158469, AF482988, AP006241, AY148488, BC051374, BU845010
      Consensus CDS
      CCDS46797.1
      UniProtKB/Swiss-Prot
      Q14524
      UniProtKB/TrEMBL
      Q86V90
      Related
      ENSP00000398266, OTTHUMP00000209282, ENST00000423572, OTTHUMT00000343225
      Conserved Domains (4) summary
      cd13433
      Location:14701522
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12401468
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531214
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    2. NM_001099404.1NP_001092874.1  sodium channel protein type 5 subunit alpha isoform c

      See identical proteins and their annotated locations for NP_001092874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as hB1, uses an alternate, duplicated coding exon compared to transcript variant 1, resulting in an isoform (c) of the same size, but differing in a few internal aa compared to isoform a.
      Source sequence(s)
      AB158469, AB208866, AF482988, AY038064, BU845010, EF629346
      Consensus CDS
      CCDS46799.1
      UniProtKB/Swiss-Prot
      Q14524
      UniProtKB/TrEMBL
      H9KVD2
      Related
      ENSP00000410257, OTTHUMP00000209281, ENST00000413689, OTTHUMT00000343224
      Conserved Domains (4) summary
      cd13433
      Location:14711523
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12411469
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531215
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    3. NM_001099405.1NP_001092875.1  sodium channel protein type 5 subunit alpha isoform d

      See identical proteins and their annotated locations for NP_001092875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as hB2, uses an alternate, duplicated coding exon, and is missing another in-frame, downstream coding exon compared to transcript variant 1, resulting in a shorter isoform (d) missing an internal segment and differing in a few aa, compared to isoform a.
      Source sequence(s)
      AB158469, AB208866, AF482988, AY038064, BU845010, EF629347
      Consensus CDS
      CCDS46798.1
      UniProtKB/Swiss-Prot
      Q14524
      UniProtKB/TrEMBL
      E9PG18
      Related
      ENSP00000416634, ENST00000425664
      Conserved Domains (4) summary
      cd13433
      Location:14531505
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12411451
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531215
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    4. NM_001160160.1NP_001153632.1  sodium channel protein type 5 subunit alpha isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate, duplicated exon in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (e) differs at a few internal aa near the N-terminus and lacks a 1-aa and a 32-aa segment, compared to isoform a.
      Source sequence(s)
      AB158469, AF482988, AY038064, BC051374, BC144621
      Consensus CDS
      CCDS54570.1
      UniProtKB/Swiss-Prot
      Q14524
      UniProtKB/TrEMBL
      E9PHB6, Q86V90
      Related
      ENSP00000399524, OTTHUMP00000209279, ENST00000455624, OTTHUMT00000343215
      Conserved Domains (4) summary
      cd13433
      Location:14701522
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12401468
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531214
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    5. NM_001160161.1NP_001153633.1  sodium channel protein type 5 subunit alpha isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate, duplicated exon in the 5' coding region and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (f) differs at a few internal aa near the N-terminus and lacks a 54-aa segment, compared to isoform a.
      Source sequence(s)
      AB158470, AF482988, AY038064, BC051374, BC140813
      Consensus CDS
      CCDS54569.1
      UniProtKB/Swiss-Prot
      Q14524
      UniProtKB/TrEMBL
      K4DIA1, Q86V90
      Related
      ENSP00000388797, ENST00000451551
      Conserved Domains (4) summary
      cd13433
      Location:14171469
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11871415
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531161
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    6. NM_198056.2NP_932173.1  sodium channel protein type 5 subunit alpha isoform a

      See identical proteins and their annotated locations for NP_932173.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AB158469, AF482988, AP006241, BU845010, M77235
      Consensus CDS
      CCDS46796.1
      UniProtKB/Swiss-Prot
      Q14524
      Related
      ENSP00000328968, OTTHUMP00000226268, ENST00000333535, OTTHUMT00000377958
      Conserved Domains (4) summary
      cd13433
      Location:14711523
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12411469
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531215
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      38548058..38649673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533991.1XP_011532293.1  

      Conserved Domains (4) summary
      cd13433
      Location:14701522
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12401468
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531214
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)
    2. XM_011533992.1XP_011532294.1  

      Conserved Domains (4) summary
      cd13433
      Location:14281480
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:11981426
      Ion_trans; Ion transport protein
      pfam06512
      Location:9101172
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:442625
      DUF3451; Domain of unknown function (DUF3451)
    3. XM_006713282.2XP_006713345.1  

      See identical proteins and their annotated locations for XP_006713345.1

      UniProtKB/Swiss-Prot
      Q14524
      Related
      ENSP00000413996, OTTHUMP00000209284, ENST00000449557, OTTHUMT00000343227
      Conserved Domains (4) summary
      cd13433
      Location:14711523
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:12411469
      Ion_trans; Ion transport protein
      pfam06512
      Location:9531215
      Na_trans_assoc; Sodium ion transport-associated
      pfam11933
      Location:485668
      DUF3451; Domain of unknown function (DUF3451)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      38541190..38642759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)