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Irak4 interleukin-1 receptor-associated kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 266632, updated on 19-Sep-2014
Official Symbol
Irak4provided by MGI
Official Full Name
interleukin-1 receptor-associated kinase 4provided by MGI
Primary source
MGI:MGI:2182474
See related
Ensembl:ENSMUSG00000059883; Vega:OTTMUSG00000016696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik
See Irak4 in Epigenomics, MapViewer
Location:
15 F1; 15
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (94543660..94568317)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20 Neighboring gene pseudouridylate synthase 7 homolog (S. cerevisiae)-like Neighboring gene uncharacterized LOC102632766 Neighboring gene twinfilin, actin-binding protein, homolog 1 (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (1) 
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
    Apoptosis signaling pathway, organism-specific biosystem
    Apoptosis signaling pathway
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Leishmaniasis, organism-specific biosystem (from KEGG)
    Leishmaniasis, organism-specific biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Leishmaniasis, conserved biosystem (from KEGG)
    Leishmaniasis, conserved biosystemLeishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and prol...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
    MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Pertussis, organism-specific biosystem (from KEGG)
    Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Pertussis, conserved biosystem (from KEGG)
    Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
    TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
    TLR4 (Toll-like receptor 4) signaling pathway
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystem (from REACTOME)
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
    Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
    Toll Like Receptor signaling, organism-specific biosystem
    Toll Like Receptor signaling
  • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
    Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toxoplasmosis, organism-specific biosystem (from KEGG)
    Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Toxoplasmosis, conserved biosystem (from KEGG)
    Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
interleukin-1 receptor-associated kinase 4
Names
interleukin-1 receptor-associated kinase 4
NP_084202.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029926.5NP_084202.2  interleukin-1 receptor-associated kinase 4

    See proteins identical to NP_084202.2

    Status: VALIDATED

    Source sequence(s)
    AK028837, AK029028, BC051676, BE635313
    Consensus CDS
    CCDS27772.1
    UniProtKB/Swiss-Prot
    Q8R4K2
    Related
    ENSMUSP00000074471, OTTMUSP00000018065, ENSMUST00000074936, OTTMUST00000040437
    Conserved Domains (3) summary
    cd00180
    Location:193380
    PKc; Catalytic domain of Protein Kinases
    smart00221
    Location:193454
    STYKc; Protein kinase; unclassified specificity
    cd08793
    Location:9108
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    94543660..94568317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    96687848..96713099
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)