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SELPLG selectin P ligand [ Homo sapiens (human) ]

Gene ID: 6404, updated on 11-Sep-2014
Official Symbol
SELPLGprovided by HGNC
Official Full Name
selectin P ligandprovided by HGNC
Primary source
HGNC:HGNC:10722
See related
Ensembl:ENSG00000110876; HPRD:02845; MIM:600738; Vega:OTTHUMG00000169411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA; CD162; PSGL1; PSGL-1
Summary
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
See SELPLG in Epigenomics, MapViewer
Location:
12q24
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (108621895..108633959, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109015671..109027735, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119 Neighboring gene microRNA 4496 Neighboring gene coronin, actin binding protein, 1C

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of conduct disorder symptomatology.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
gag HIV-1 Gag co-localizes with both uropod markers PSGL-1 and CD43 on the plasma membrane PubMed

Go to the HIV-1, Human Interaction Database

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte adhesive activation ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
P-selectin glycoprotein ligand 1
Names
P-selectin glycoprotein ligand 1
cutaneous lymphocyte-associated associated antigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206609.1NP_001193538.1  P-selectin glycoprotein ligand 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007569, AC008119, AK298742, BC029782, CA427270, DC339004
    Consensus CDS
    CCDS55881.1
    UniProtKB/Swiss-Prot
    Q14242
    Conserved Domains (1) summary
    PRK10811
    Location:136295
    rne; ribonuclease E; Reviewed
  2. NM_003006.4NP_002997.2  P-selectin glycoprotein ligand 1 isoform 2 precursor

    See proteins identical to NP_002997.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008119, AK098315, AK225644
    Consensus CDS
    CCDS31895.2
    UniProtKB/Swiss-Prot
    Q14242
    Related
    ENSP00000447752, OTTHUMP00000241014, ENST00000550948, OTTHUMT00000403904
    Conserved Domains (1) summary
    PRK10811
    Location:120279
    rne; ribonuclease E; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    108621895..108633959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269077.1XP_005269134.1  

    Conserved Domains (1) summary
    cl00788
    Location:105216
    MttA_Hcf106; mttA/Hcf106 family
  2. XM_005269076.1XP_005269133.1  

    See proteins identical to XP_005269133.1

    UniProtKB/Swiss-Prot
    Q14242
    Conserved Domains (1) summary
    cl00788
    Location:105208
    MttA_Hcf106; mttA/Hcf106 family
  3. XM_006719557.1XP_006719620.1  

    Conserved Domains (1) summary
    PRK10811
    Location:120278
    rne; ribonuclease E; Reviewed

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    106080035..106092040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    108982422..108994418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)