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    Nup98 nucleoporin 98 [ Mus musculus (house mouse) ]

    Gene ID: 269966, updated on 3-Apr-2016
    Official Symbol
    Nup98provided by MGI
    Official Full Name
    nucleoporin 98provided by MGI
    Primary source
    MGI:MGI:109404
    See related
    Ensembl:ENSMUSG00000063550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nup96; AI849286; 4732457F17
    Orthologs
    Location:
    7 E2; 7 54.71 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (102119400..102210166, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109282717..109358634, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 5 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene predicted gene, 39062 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Nuclear pore complex, conserved biosystem (from KEGG)
      Nuclear pore complex, conserved biosystemStructural complex; Genetic information processing; RNA processing
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC118567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear localization sequence binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleocytoplasmic transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein import into nucleus, docking ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    telomere tethering at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore cytoplasmic filaments IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pore outer ring ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    nuclear pore complex protein Nup98-Nup96

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287164.1NP_001274093.1  nuclear pore complex protein Nup98-Nup96 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001274093.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC118592, AK028800, BC050911, BC078630
      UniProtKB/Swiss-Prot
      Q6PFD9
      Conserved Domains (3) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13281626
      Nup96; Nuclear protein 96
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    2. NM_001287165.1NP_001274094.1  nuclear pore complex protein Nup98-Nup96 isoform 3

      See identical proteins and their annotated locations for NP_001274094.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      B2RQL0, Q4FZE7
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    3. NM_001287166.1NP_001274095.1  nuclear pore complex protein Nup98-Nup96 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple coding region differences compared to variant 1 and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK164402
      UniProtKB/TrEMBL
      Q3TPG3
      Conserved Domains (2) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    4. NM_001287167.1NP_001274096.1  nuclear pore complex protein Nup98-Nup96 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks several exons, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 5 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, AK146491
      UniProtKB/TrEMBL
      Q3UJE5
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    5. NM_022979.2NP_075355.1  nuclear pore complex protein Nup98-Nup96 isoform 2

      See identical proteins and their annotated locations for NP_075355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC118592, BC050911, BC099600
      Consensus CDS
      CCDS21528.1
      UniProtKB/Swiss-Prot
      Q6PFD9
      UniProtKB/TrEMBL
      Q4FZE7
      Related
      ENSMUSP00000068530, ENSMUST00000070165
      Conserved Domains (2) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

      Range
      102119400..102210166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507896.1XP_006507959.1  

      Conserved Domains (3) summary
      pfam04096
      Location:723863
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13111609
      Nup96; Nuclear protein 96
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    2. XM_006507897.1XP_006507960.1  

      Conserved Domains (3) summary
      pfam04096
      Location:693833
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:12811579
      Nup96; Nuclear protein 96
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region
    3. XM_006507895.1XP_006507958.1  

      See identical proteins and their annotated locations for XP_006507958.1

      Conserved Domains (3) summary
      pfam04096
      Location:740880
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:13281626
      Nup96; Nuclear protein 96
      pfam13634
      Location:39149
      Nucleoporin_FG; Nucleoporin FG repeat region

    Alternate Mm_Celera

    Genomic

    1. AC_000029.1 Alternate Mm_Celera

      Range
      102486463..102578202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)