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    Crhr2 corticotropin releasing hormone receptor 2 [ Mus musculus (house mouse) ]

    Gene ID: 12922, updated on 3-Jul-2016
    Official Symbol
    Crhr2provided by MGI
    Official Full Name
    corticotropin releasing hormone receptor 2provided by MGI
    Primary source
    MGI:MGI:894312
    See related
    Ensembl:ENSMUSG00000003476 Vega:OTTMUSG00000035963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crfr2; CRF-R2; CRFR2beta; CRFR2alpha
    Orthologs
    Location:
    6 B3; 6 27.33 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (55090048..55133016, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (55040042..55082966, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38539 Neighboring gene glycyl-tRNA synthetase Neighboring gene predicted gene, 34358 Neighboring gene indolethylamine N-methyltransferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    corticotrophin-releasing factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    corticotropin-releasing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    catecholamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    gastric motility ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of defecation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of serotonin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle tissue growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    varicosity ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    corticotropin-releasing factor receptor 2
    Names
    CRF 2 receptor
    CRF-R-2
    CRF-RB
    CRFR-2
    CRH-R-2
    CRH-R2
    corticotropin releasing factor receptor type 2 beta
    corticotropin-releasing factor 2
    corticotropin-releasing hormone receptor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001288618.1NP_001275547.1  corticotropin-releasing factor receptor 2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK085854, AK142261, CJ065172
      UniProtKB/TrEMBL
      Q3UQP0
      Conserved Domains (2) summary
      smart00008
      Location:56127
      HormR; Domain present in hormone receptors
      pfam00002
      Location:133375
      7tm_2; 7 transmembrane receptor (Secretin family)
    2. NM_001288619.1NP_001275548.1  corticotropin-releasing factor receptor 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001275548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK142261, AY445512
      UniProtKB/Swiss-Prot
      Q60748
      UniProtKB/TrEMBL
      Q3UQP0
      Conserved Domains (2) summary
      smart00008
      Location:36107
      HormR; Domain present in hormone receptors
      pfam00002
      Location:113355
      7tm_2; 7 transmembrane receptor (Secretin family)
    3. NM_001288620.1NP_001275549.1  corticotropin-releasing factor receptor 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK142261, AY753668
      UniProtKB/TrEMBL
      Q3UQP0, Q5ERJ2
      Conserved Domains (1) summary
      pfam00002
      Location:37250
      7tm_2; 7 transmembrane receptor (Secretin family)
    4. NM_009953.4NP_034083.2  corticotropin-releasing factor receptor 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034083.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but lacks an alternate internal aa compared to isoform 1.
      Source sequence(s)
      AK085854, AK142261
      Consensus CDS
      CCDS20162.1
      UniProtKB/TrEMBL
      Q3UQP0
      Related
      ENSMUSP00000003568, OTTMUSP00000050946, ENSMUST00000003568, OTTMUST00000092261
      Conserved Domains (2) summary
      smart00008
      Location:56127
      HormR; Domain present in hormone receptors
      pfam00002
      Location:132374
      7tm_2; 7 transmembrane receptor (Secretin family)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      55090048..55133016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505482.3XP_006505545.1  

      UniProtKB/TrEMBL
      E9QNK5
      Related
      ENSMUSP00000110015, OTTMUSP00000050948, ENSMUST00000114374, OTTMUST00000092263
      Conserved Domains (2) summary
      smart00008
      Location:36107
      HormR; Domain present in hormone receptors
      pfam00002
      Location:112354
      7tm_2; 7 transmembrane receptor (Secretin family)