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    Flt3 FMS-like tyrosine kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 14255, updated on 24-Jun-2016
    Official Symbol
    Flt3provided by MGI
    Official Full Name
    FMS-like tyrosine kinase 3provided by MGI
    Primary source
    MGI:MGI:95559
    See related
    Ensembl:ENSMUSG00000042817 Vega:OTTMUSG00000020408
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
    Orthologs
    Location:
    5 86.88 cM; 5 G3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (147330741..147400489, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (148142317..148212065, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase Neighboring gene predicted gene, 29778 Neighboring gene predicted gene, 29793 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124377, MGC124378

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    glucocorticoid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    antigen processing and presentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cytokine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    common myeloid progenitor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    common myeloid progenitor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    leukocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    lymphoid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myeloid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    myeloid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of B cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-alpha secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interferon-gamma secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pro-B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    pro-T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    receptor-type tyrosine-protein kinase FLT3
    Names
    FL cytokine receptor
    fetal liver kinase 2
    tyrosine-protein kinase FLT3
    tyrosine-protein kinase receptor flk-2
    NP_034359.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010229.2NP_034359.2  receptor-type tyrosine-protein kinase FLT3 precursor

      See identical proteins and their annotated locations for NP_034359.2

      Status: VALIDATED

      Source sequence(s)
      AK149292, AK163640, X59398
      Consensus CDS
      CCDS39400.1
      UniProtKB/Swiss-Prot
      Q00342
      UniProtKB/TrEMBL
      Q3TQF1, Q3UEW6
      Related
      ENSMUSP00000039041, OTTMUSP00000022189, ENSMUST00000049324, OTTMUST00000048424
      Conserved Domains (3) summary
      pfam00047
      Location:266332
      ig; Immunoglobulin domain
      pfam07714
      Location:611946
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:573950
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      147330741..147400489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504805.2XP_006504868.1  

      Conserved Domains (2) summary
      pfam07714
      Location:181516
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:143520
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006504804.2XP_006504867.1  

      Conserved Domains (2) summary
      pfam07714
      Location:233568
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:195572
      PKc_like; Protein Kinases, catalytic domain

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      145322183..145394029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)