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SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) [ Homo sapiens (human) ]

Gene ID: 6829, updated on 7-Dec-2014
Official Symbol
SUPT5Hprovided by HGNC
Official Full Name
suppressor of Ty 5 homolog (S. cerevisiae)provided by HGNC
Primary source
HGNC:HGNC:11469
See related
Ensembl:ENSG00000196235; HPRD:03655; MIM:602102; Vega:OTTHUMG00000182973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPT5; SPT5H; Tat-CT1
See SUPT5H in Epigenomics, MapViewer
Location:
19q13
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (39445546..39476670)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39936186..39967310)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S16 Neighboring gene interleukin-like Neighboring gene translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) Neighboring gene delta-like 3 (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces the phosphorylation of the SPT5 CTR1 domain (amino acids 754-817) by CDK9/P-TEFb PubMed
tat The SPT5/SPT4 complex, DSIF, associates with the HIV-1 transcription elongation complex (TEC) and SPT5 cooperates with HIV-1 Tat by preventing premature RNA release from the TEC at terminator sequences and reducing polymerase pausing at arrest sites PubMed
tat SPT5 associates with the HIV-1 Tat cofactor Tat-SF1 and the RNA polymerase II holoenzyme and stimulates Tat-mediated transcriptional activation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
7-methylguanosine mRNA capping TAS
Traceable Author Statement
more info
 
DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
gene expression TAS
Traceable Author Statement
more info
 
negative regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-templated transcription, elongation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of viral transcription TAS
Traceable Author Statement
more info
 
response to organic substance TAS
Traceable Author Statement
more info
PubMed 
single stranded viral RNA replication via double stranded DNA intermediate NAS
Non-traceable Author Statement
more info
PubMed 
transcription elongation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DSIF complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription elongation factor SPT5
Names
transcription elongation factor SPT5
hSPT5
DSIF p160
DSIF large subunit
Tat-cotransactivator 1 protein
DRB sensitivity-inducing factor large subunit
DRB sensitivity-inducing factor 160 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111020.2NP_001104490.1  transcription elongation factor SPT5 isoform a

    See proteins identical to NP_001104490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AF040253, DB097498
    Consensus CDS
    CCDS12536.1
    UniProtKB/Swiss-Prot
    O00267
    Related
    ENSP00000470252, OTTHUMP00000270775, ENST00000599117, OTTHUMT00000464918
    Conserved Domains (12) summary
    PRK08559
    Location:175316
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:178265
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:772889
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:334965
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:276313
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:420470
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:471521
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:597639
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:702751
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10281084
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:846978
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85172
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
  2. NM_001130824.1NP_001124296.1  transcription elongation factor SPT5 isoform a

    See proteins identical to NP_001124296.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AF040253, BC024203, DB097498, Y12790
    Consensus CDS
    CCDS12536.1
    UniProtKB/Swiss-Prot
    O00267
    Conserved Domains (12) summary
    PRK08559
    Location:175316
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:178265
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:772889
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:334965
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:276313
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:420470
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:471521
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:597639
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:702751
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10281084
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:846978
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85172
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
  3. NM_001130825.1NP_001124297.1  transcription elongation factor SPT5 isoform b

    See proteins identical to NP_001124297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alterate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AB209257, AF040253, DB097498
    Consensus CDS
    CCDS46072.1
    UniProtKB/Swiss-Prot
    O00267
    Related
    ENSP00000384505, ENST00000402194
    Conserved Domains (12) summary
    PRK08559
    Location:171312
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:174261
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:768885
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:330961
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:272309
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:416466
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:467517
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:593635
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:698747
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10241080
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:842974
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85168
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
  4. NM_003169.3NP_003160.2  transcription elongation factor SPT5 isoform a

    See proteins identical to NP_003160.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Variants 1, 2, and 3 all encode the same isoform.
    Source sequence(s)
    AF040253, BP199253
    Consensus CDS
    CCDS12536.1
    UniProtKB/Swiss-Prot
    O00267
    Related
    ENSP00000469090, OTTHUMP00000270778, ENST00000598725, OTTHUMT00000464925
    Conserved Domains (12) summary
    PRK08559
    Location:175316
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:178265
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:772889
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:334965
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:276313
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:420470
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:471521
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:597639
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:702751
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10281084
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:846978
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85172
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    39445546..39476670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259183.1XP_005259240.1  

    See proteins identical to XP_005259240.1

    UniProtKB/Swiss-Prot
    O00267
    Conserved Domains (12) summary
    PRK08559
    Location:175316
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:178265
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:772889
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:334965
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:276313
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:420470
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:471521
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:597639
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:702751
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10281084
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:846978
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85172
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal
  2. XM_006723337.1XP_006723400.1  

    See proteins identical to XP_006723400.1

    UniProtKB/Swiss-Prot
    O00267
    Conserved Domains (12) summary
    PRK08559
    Location:171312
    nusG; transcription antitermination protein NusG; Validated
    cd09888
    Location:174261
    NGN_Euk; Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1)
    smart01104
    Location:768885
    CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
    COG5164
    Location:330961
    SPT5; Transcription elongation factor [Transcription]
    cd06081
    Location:272309
    KOW_Spt5_1; KOW domain of Spt5, repeat 1
    cd06082
    Location:416466
    KOW_Spt5_2; KOW domain of Spt5, repeat 2
    cd06083
    Location:467517
    KOW_Spt5_3; KOW domain of Spt5, repeat 3
    cd06084
    Location:593635
    KOW_Spt5_4; KOW domain of Spt5, repeat 4
    cd06085
    Location:698747
    KOW_Spt5_5; KOW domain of Spt5, repeat 5
    cd06086
    Location:10241080
    KOW_Spt5_6; KOW domain of Spt5, repeat 6
    pfam04731
    Location:842974
    Caudal_act; Caudal like protein activation region
    pfam11942
    Location:85168
    Spt5_N; Spt5 transcription elongation factor, acidic N-terminal

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    39936824..39967943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    36382774..36413888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)