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Trem2 triggering receptor expressed on myeloid cells 2 [ Mus musculus (house mouse) ]

Gene ID: 83433, updated on 7-Aug-2014
Official Symbol
Trem2provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 2provided by MGI
Primary source
MGI:1913150
See related
Ensembl:ENSMUSG00000023992; Vega:OTTMUSG00000021045
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TREM-2; Trem2a; Trem2b; Trem2c
Summary
The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
See Trem2 in Epigenomics, MapViewer
Location:
17 C; 17
Exon count:
5
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (48346401..48352276)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene triggering receptor expressed on myeloid cells-like 2 Neighboring gene RIKEN cDNA B430306N03 gene Neighboring gene triggering receptor expressed on myeloid cells-like 1 Neighboring gene nuclear transcription factor-Y alpha

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
lipoteichoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
peptidoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cellular response to lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
detection of lipoteichoic acid IDA
Inferred from Direct Assay
more info
PubMed 
detection of peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IC
Inferred by Curator
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IC
Inferred by Curator
more info
PubMed 
positive regulation of C-C chemokine receptor CCR7 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of antigen processing and presentation of peptide antigen via MHC class II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
triggering receptor expressed on myeloid cells 2
Names
triggering receptor expressed on myeloid cells 2
triggering receptor expressed on monocytes 2
triggering receptor expressed on myeloid cells 2a
triggering receptor expressed on myeloid cells 2b
triggering receptor expressed on myeloid cells 2c

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272078.1NP_001259007.1  triggering receptor expressed on myeloid cells 2 isoform 2 precursor

    See proteins identical to NP_001259007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus that lacks a transmembrane domain, compared to isoform 1.
    Source sequence(s)
    AC166164, AK039477, AY187009, BY541740
    Consensus CDS
    CCDS70825.1
    UniProtKB/Swiss-Prot
    Q99NH8
    Related
    ENSMUSP00000108863, OTTMUSP00000023120, ENSMUST00000113237, OTTMUST00000049782
    Conserved Domains (1) summary
    cl11960
    Location:23128
    Blast Score: 128
    Ig; Immunoglobulin domain
  2. NM_031254.3NP_112544.1  triggering receptor expressed on myeloid cells 2 isoform 1 precursor

    See proteins identical to NP_112544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC166164, AK039477, BY541740
    Consensus CDS
    CCDS28865.1
    UniProtKB/Swiss-Prot
    Q99NH8
    Related
    ENSMUSP00000024791, OTTMUSP00000023119, ENSMUST00000024791, OTTMUST00000049781
    Conserved Domains (2) summary
    smart00410
    Location:23111
    Blast Score: 77
    IG_like; Immunoglobulin like
    cl11960
    Location:23128
    Blast Score: 132
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    48346401..48352276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    51775275..51781150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)