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    Cd274 CD274 antigen [ Mus musculus (house mouse) ]

    Gene ID: 60533, updated on 17-Aug-2016
    Official Symbol
    Cd274provided by MGI
    Official Full Name
    CD274 antigenprovided by MGI
    Primary source
    MGI:MGI:1926446
    See related
    Ensembl:ENSMUSG00000016496 Vega:OTTMUSG00000014904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
    Summary
    The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    19; 19 C2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (29367438..29388095)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29441928..29462585)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene relaxin 1 Neighboring gene plasminogen receptor, C-terminal lysine transmembrane protein Neighboring gene predicted gene, 36043 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene RIKEN cDNA A930007I19 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor superfamily cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-10 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    programmed cell death 1 ligand 1
    Names
    B7 homolog 1
    PDCD1 ligand 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021893.3NP_068693.1  programmed cell death 1 ligand 1 precursor

      See identical proteins and their annotated locations for NP_068693.1

      Status: REVIEWED

      Source sequence(s)
      AC119228, AF317088, AI645624, BY193530
      Consensus CDS
      CCDS29735.1
      UniProtKB/Swiss-Prot
      Q9EP73
      UniProtKB/TrEMBL
      Q3U472
      Related
      ENSMUSP00000016640, OTTMUSP00000015826, ENSMUST00000016640, OTTMUST00000035406
      Conserved Domains (2) summary
      smart00410
      Location:24130
      IG_like; Immunoglobulin like
      cl11960
      Location:33119
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      29367438..29388095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)