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    Aif1 allograft inflammatory factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29427, updated on 8-Aug-2016
    Official Symbol
    Aif1provided by RGD
    Official Full Name
    allograft inflammatory factor 1provided by RGD
    Primary source
    RGD:61924
    See related
    Ensembl:ENSRNOG00000000853 Vega:OTTRNOG00000000741
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    iba1; Bart1; mrf-1; BART-1
    Summary
    may play a role in macrophage activation and function [RGD, Feb 2006]
    Orthologs
    Location:
    20p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5161350..5167176, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (7234609..7240454, complement)

    Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene proline-rich coiled-coil 2A Neighboring gene E230034O05Rik gene Neighboring gene natural cytotoxicity triggering receptor 3 Neighboring gene leukocyte specific transcript 1 Neighboring gene lymphotoxin beta

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Rac protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament bundle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to extracellular stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hydroperoxide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interferon-gamma IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to morphine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    inflammatory response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    macrophage activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of G1/S transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of monocyte chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of muscle hyperplasia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to electrical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ruffle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytic cup ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ruffle ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    allograft inflammatory factor 1
    Names
    AIF-1
    balloon angioplasty responsive transcript
    balloon angioplasty-responsive transcript 1
    ionized calcium binding adapter molecule 1
    ionized calcium-binding adapter molecule 1
    microglia response factor
    protein BART-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017196.3NP_058892.1  allograft inflammatory factor 1

      See identical proteins and their annotated locations for NP_058892.1

      Status: VALIDATED

      Source sequence(s)
      BC081822, BX883046, FM053942
      UniProtKB/Swiss-Prot
      P55009
      Related
      ENSRNOP00000001135, OTTRNOP00000000552, ENSRNOT00000001135, OTTRNOT00000001087
      Conserved Domains (1) summary
      cl08302
      Location:48110
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005119.4 Reference Rnor_6.0 Primary Assembly

      Range
      5161350..5167176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256063.3XP_006256125.1  

      See identical proteins and their annotated locations for XP_006256125.1

      Conserved Domains (2) summary
      cd00051
      Location:149202
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:148202
      EF-hand_7; EF-hand domain pair
    2. XM_006256065.2XP_006256127.1  

      See identical proteins and their annotated locations for XP_006256127.1

      UniProtKB/Swiss-Prot
      P55009
      UniProtKB/TrEMBL
      F1LRC2
      Related
      ENSRNOP00000068279, OTTRNOP00000000551, ENSRNOT00000076331, OTTRNOT00000001086
      Conserved Domains (1) summary
      cl08302
      Location:47109
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_006256062.2XP_006256124.1  

      See identical proteins and their annotated locations for XP_006256124.1

      Conserved Domains (2) summary
      cd00051
      Location:149202
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:148202
      EF-hand_7; EF-hand domain pair
    4. XM_006256061.3XP_006256123.1  

      Conserved Domains (2) summary
      cd00051
      Location:150203
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:149203
      EF-hand_7; EF-hand domain pair

    Alternate Rn_Celera

    Genomic

    1. AC_000088.1 Alternate Rn_Celera

      Range
      4373127..4375026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)