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Sod2 superoxide dismutase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 24787, updated on 14-Sep-2014
Official Symbol
Sod2provided by RGD
Official Full Name
superoxide dismutase 2, mitochondrialprovided by RGD
Primary source
RGD:3732
See related
Ensembl:ENSRNOG00000019048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
manganese superoxide dismutase; intramitochondrial free radical scavenging enzyme [RGD, Feb 2006]
See Sod2 in MapViewer
Location:
1q21
Exon count:
5
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47914757..47921587, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (51827380..51834232)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 1 Neighboring gene uncharacterized LOC103690969 Neighboring gene hypothetical protein LOC680622 Neighboring gene uncharacterized LOC102553528 Neighboring gene Wilms tumor 1 associated protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
oxygen binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 
superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide dismutase activity ISO
Inferred from Sequence Orthology
more info
 
superoxide dismutase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
age-dependent response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
age-dependent response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
age-dependent response to reactive oxygen species ISS
Inferred from Sequence or Structural Similarity
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic mitochondrial changes ISO
Inferred from Sequence Orthology
more info
 
cellular response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
detection of oxygen IEA
Inferred from Electronic Annotation
more info
 
detection of oxygen ISO
Inferred from Sequence Orthology
more info
 
erythrophore differentiation IEA
Inferred from Electronic Annotation
more info
 
erythrophore differentiation ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
neuron development ISO
Inferred from Sequence Orthology
more info
 
oxygen homeostasis IEA
Inferred from Electronic Annotation
more info
 
oxygen homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
removal of superoxide radicals IDA
Inferred from Direct Assay
more info
PubMed 
removal of superoxide radicals ISO
Inferred from Sequence Orthology
more info
 
removal of superoxide radicals TAS
Traceable Author Statement
more info
PubMed 
respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
respiratory electron transport chain ISO
Inferred from Sequence Orthology
more info
 
response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to activity ISO
Inferred from Sequence Orthology
more info
 
response to axon injury IEA
Inferred from Electronic Annotation
more info
 
response to axon injury ISO
Inferred from Sequence Orthology
more info
 
response to cadmium ion IEP
Inferred from Expression Pattern
more info
 
response to cold IEP
Inferred from Expression Pattern
more info
 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to electrical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
response to hyperoxia ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEP
Inferred from Expression Pattern
more info
 
response to isolation stress IEP
Inferred from Expression Pattern
more info
 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
response to magnetism IEP
Inferred from Expression Pattern
more info
 
response to manganese ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to nutrient levels IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IEP
Inferred from Expression Pattern
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to radiation IEP
Inferred from Expression Pattern
more info
 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
response to selenium ion IEP
Inferred from Expression Pattern
more info
PubMed 
response to silicon dioxide IEP
Inferred from Expression Pattern
more info
PubMed 
response to superoxide ISO
Inferred from Sequence Orthology
more info
 
response to zinc ion IEP
Inferred from Expression Pattern
more info
 
NOT sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process ISO
Inferred from Sequence Orthology
more info
 
superoxide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
vasodilation ISO
Inferred from Sequence Orthology
more info
 
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicular exosome IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
superoxide dismutase [Mn], mitochondrial
Names
superoxide dismutase [Mn], mitochondrial
Superoxide dimutase 2, mitochondrial
mitochondrial superoxide dismutase 2
NP_058747.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017051.2NP_058747.1  superoxide dismutase [Mn], mitochondrial precursor

    See proteins identical to NP_058747.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070913
    UniProtKB/Swiss-Prot
    P07895
    Related
    ENSRNOP00000025794, ENSRNOT00000025794
    Conserved Domains (3) summary
    COG0605
    Location:25217
    SodA; Superoxide dismutase [Inorganic ion transport and metabolism]
    pfam00081
    Location:25106
    Sod_Fe_N; Iron/manganese superoxide dismutases, alpha-hairpin domain
    pfam02777
    Location:111217
    Sod_Fe_C; Iron/manganese superoxide dismutases, C-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 

    Range
    47914757..47921587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 

    Range
    43323111..43329909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)