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Ang angiogenin, ribonuclease, RNase A family, 5 [ Mus musculus (house mouse) ]

Gene ID: 11727, updated on 19-Jul-2014
Official Symbol
Angprovided by MGI
Official Full Name
angiogenin, ribonuclease, RNase A family, 5provided by MGI
Primary source
MGI:88022
See related
Ensembl:ENSMUSG00000072115
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ang1; Rnase5; Rnase5a; AI385586
Summary
This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. [provided by RefSeq, Jun 2009]
Location:
14 B-C1; 14 26.37 cM
Exon count:
3
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (51091077..51102009)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA tyrosine 10 (anticodon GTA) Neighboring gene nuclear encoded tRNA proline 15 (anticodon TGG) Neighboring gene ribonuclease, RNase A family 4 Neighboring gene epididymal protein 3B Neighboring gene ribonuclease, RNase A family, 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IC
Inferred by Curator
more info
PubMed 
actin binding ISO
Inferred from Sequence Orthology
more info
 
copper ion binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
peptide binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
ribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis ISO
Inferred from Sequence Orthology
more info
 
activation of phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
diacylglycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of translation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
rRNA transcription ISO
Inferred from Sequence Orthology
more info
 
response to hormone ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
angiogenin-PRI complex ISO
Inferred from Sequence Orthology
more info
 
basal lamina ISO
Inferred from Sequence Orthology
more info
 
basement membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
angiogenin
Names
angiogenin
RNase 5
angiogenin-1
ribonuclease 5
angiogenin, ribonuclease A family, member 1
NP_001155203.1
NP_031473.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161731.2NP_001155203.1  angiogenin precursor

    See proteins identical to NP_001155203.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC163664, AW122635, BF721354
    Consensus CDS
    CCDS27034.1
    UniProtKB/Swiss-Prot
    P21570
    UniProtKB/TrEMBL
    Q3TBG7
    Related
    ENSMUSP00000132084, ENSMUST00000171688
    Conserved Domains (1) summary
    cd06265
    Location:28140
    Blast Score: 389
    RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have ...
  2. NM_007447.3NP_031473.1  angiogenin precursor

    See proteins identical to NP_031473.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK159966, AW122635
    Consensus CDS
    CCDS27034.1
    UniProtKB/Swiss-Prot
    P21570
    UniProtKB/TrEMBL
    Q3TBG7
    Related
    ENSMUSP00000067434, ENSMUST00000069011
    Conserved Domains (1) summary
    cd06265
    Location:28140
    Blast Score: 389
    RNase_A_canonical; Canonical RNase A family includes all vertebrate homologues to the bovine pancreatic ribonuclease A (RNase A) that contain the catalytic site, necessary for RNase activity. In the human genome 8 RNases , refered to as "canonical" RNases, have ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    51091077..51102009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    47385172..47396946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)