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Gfap glial fibrillary acidic protein [ Mus musculus (house mouse) ]

Gene ID: 14580, updated on 23-Jul-2014
Official Symbol
Gfapprovided by MGI
Official Full Name
glial fibrillary acidic proteinprovided by MGI
Primary source
MGI:95697
See related
Ensembl:ENSMUSG00000020932; Vega:OTTMUSG00000003084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI836096
See Gfap in Epigenomics, MapViewer
Location:
11 D; 11 66.48 cM
Exon count:
11
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (102887336..102897433, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene HIG1 domain family, member 1B Neighboring gene elongation factor Tu GTP binding domain containing 2 Neighboring gene coiled-coil domain containing 103 Neighboring gene family with sequence similarity 187, member A Neighboring gene uncharacterized LOC102637855 Neighboring gene kinesin family member 18B Neighboring gene complement component 1, q subcomponent-like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
integrin binding ISO
Inferred from Sequence Orthology
more info
 
kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
Bergmann glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermediate filament organization IGI
Inferred from Genetic Interaction
more info
PubMed 
intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
intermediate filament-based process IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
glial fibrillary acidic protein
Names
glial fibrillary acidic protein
intermediate filament protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131020.1NP_001124492.1  glial fibrillary acidic protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK140151, BC139357, BU700210
    Consensus CDS
    CCDS48950.1
    UniProtKB/Swiss-Prot
    P03995
    Related
    ENSMUSP00000077061, ENSMUST00000077902
    Conserved Domains (3) summary
    pfam00038
    Location:65373
    Blast Score: 947
    Filament; Intermediate filament protein
    cl17687
    Location:187282
    Blast Score: 91
    5_nucleotid; 5' nucleotidase family
    pfam04732
    Location:463
    Blast Score: 99
    Filament_head; Intermediate filament head (DNA binding) region
  2. NM_010277.3NP_034407.2  glial fibrillary acidic protein isoform 2

    See proteins identical to NP_034407.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus when compared to isoform 1.
    Source sequence(s)
    AI835063, AK079577, BC139357, BE651678, CX223233
    Consensus CDS
    CCDS25507.1
    UniProtKB/Swiss-Prot
    P03995
    Related
    ENSMUSP00000064691, OTTMUSP00000002989, ENSMUST00000067444, OTTMUST00000006346
    Conserved Domains (3) summary
    pfam00038
    Location:65373
    Blast Score: 937
    Filament; Intermediate filament protein
    cl17687
    Location:187282
    Blast Score: 90
    5_nucleotid; 5' nucleotidase family
    pfam04732
    Location:463
    Blast Score: 97
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    102887336..102897433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532222.1XP_006532285.1  

    Conserved Domains (3) summary
    pfam00038
    Location:65373
    Blast Score: 959
    Filament; Intermediate filament protein
    cl17687
    Location:187282
    Blast Score: 90
    5_nucleotid; 5' nucleotidase family
    pfam04732
    Location:463
    Blast Score: 96
    Filament_head; Intermediate filament head (DNA binding) region

RNA

  1. XR_388347.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    114598382..114608239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)