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SPP1 secreted phosphoprotein 1 [ Sus scrofa (pig) ]

Gene ID: 397087, updated on 10-Sep-2014
Gene symbol
SPP1
Gene description
secreted phosphoprotein 1
See related
Ensembl:ENSSSCG00000009216; Vega:OTTSUSG00000000904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus
See SPP1 in MapViewer
Location:
8q; 8
Exon count:
8
Annotation release Status Assembly Chr Location
104 current Sscrofa10.2 (GCF_000003025.5) 8 NC_010450.3 (140273369..140315456, complement)

Chromosome 8 - NC_010450.3Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette sub-family G member 2-like Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2 Neighboring gene polycystic kidney disease 2 (autosomal dominant) Neighboring gene uncharacterized LOC102159130 Neighboring gene uncharacterized LOC102159211

Genomic Sequence:
NC_010450.3 chromosome 8 reference Sscrofa10.2 Primary Assembly

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ECM-receptor interaction, organism-specific biosystem (from KEGG)
    ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • ECM-receptor interaction, conserved biosystem (from KEGG)
    ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by PDGF, organism-specific biosystem (from REACTOME)
    Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
  • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
    Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...

Markers

Gene Ontology Provided by GO

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
osteopontin
Names
osteopontin
SPP-1
bone sialoprotein 1
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214023.1NP_999188.1  osteopontin precursor

    See proteins identical to NP_999188.1

    Status: VALIDATED

    Source sequence(s)
    X16575
    UniProtKB/TrEMBL
    D0G7G0
    UniProtKB/Swiss-Prot
    P14287
    Related
    ENSSSCP00000009825, OTTSUSP00000001267, ENSSSCT00000010091, OTTSUST00000001845
    Conserved Domains (1) summary
    smart00017
    Location:17303
    OSTEO; Osteopontin

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa10.2 Primary Assembly

Genomic

  1. NC_010450.3 

    Range
    140273369..140315456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005667005.1XP_005667062.1  

    Conserved Domains (1) summary
    smart00017
    Location:17302
    OSTEO; Osteopontin
  2. XM_005667006.1XP_005667063.1  

    Conserved Domains (1) summary
    pfam00865
    Location:20289
    Osteopontin; Osteopontin
  3. XM_005667004.1XP_005667061.1  

    See proteins identical to XP_005667061.1

    UniProtKB/TrEMBL
    D0G7G0
    UniProtKB/Swiss-Prot
    P14287
    Conserved Domains (1) summary
    smart00017
    Location:17303
    OSTEO; Osteopontin
  4. XM_005667008.1XP_005667065.1  

    Conserved Domains (1) summary
    pfam00865
    Location:23262
    Osteopontin; Osteopontin
  5. XM_005667007.1XP_005667064.1  

    Conserved Domains (1) summary
    pfam00865
    Location:32276
    Osteopontin; Osteopontin

RNA

  1. XR_305125.1 RNA Sequence