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Arrb2 arrestin, beta 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25388, updated on 6-Jul-2014
Official Symbol
Arrb2provided by RGD
Official Full Name
arrestin, beta 2provided by RGD
Primary source
RGD:2157
See related
Ensembl:ENSRNOG00000019308
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
BARRES
Annotation information
Annotation category: partial on reference assembly
See Arrb2 in MapViewer
Location:
10q24
Exon count :
15
Annotation release Status Assembly Chr Location
104 current Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (56797489..56805282)

Chromosome 10 - NC_005109.3Genomic Context describing neighboring genes Neighboring gene arachidonate 15-lipoxygenase Neighboring gene proline, glutamate and leucine rich protein 1 Neighboring gene mediator complex subunit 11 Neighboring gene chemokine (C-X-C motif) ligand 16 Neighboring gene zinc finger, MYND-type containing 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
D1 dopamine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
G-protein coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor binding TAS
Traceable Author Statement
more info
PubMed 
alpha-1A adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha-1B adrenergic receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin receptor binding ISO
Inferred from Sequence Orthology
more info
 
clathrin binding TAS
Traceable Author Statement
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
follicle-stimulating hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein complex scaffold IEA
Inferred from Electronic Annotation
more info
 
protein complex scaffold ISO
Inferred from Sequence Orthology
more info
 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase B binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
type 1 angiotensin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 2A serotonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Not type 2A serotonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor internalization IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adult walking behavior IEA
Inferred from Electronic Annotation
more info
 
adult walking behavior ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
desensitization of G-protein coupled receptor protein signaling pathway by arrestin IMP
Inferred from Mutant Phenotype
more info
 
desensitization of G-protein coupled receptor protein signaling pathway by arrestin ISO
Inferred from Sequence Orthology
more info
 
desensitization of G-protein coupled receptor protein signaling pathway by arrestin TAS
Traceable Author Statement
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 
endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
follicle-stimulating hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
negative regulation of natural killer cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
negative regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, dopaminergic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, dopaminergic ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
regulation of G-protein coupled receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G-protein coupled receptor protein signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of androgen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cAMP biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
regulation of cAMP catabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
endocytic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
beta-arrestin-2
Names
beta-arrestin-2
arrestin beta-2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012911.1NP_037043.1  beta-arrestin-2

    See proteins identical to NP_037043.1

    Status: PROVISIONAL

    Source sequence(s)
    M91590
    UniProtKB/Swiss-Prot
    P29067
    Related
    ENSRNOP00000026207, ENSRNOT00000026207
    Conserved Domains (2) summary
    smart01017
    Location:199350
    Blast Score: 315
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:19175
    Blast Score: 326
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

  1. NC_005109.3 

    Range
    56797489..56805282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 

    Range
    54285120..54301063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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