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CD5 CD5 molecule [ Homo sapiens (human) ]

Gene ID: 921, updated on 12-May-2015
Official Symbol
CD5provided by HGNC
Official Full Name
CD5 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1685
See related
Ensembl:ENSG00000110448; HPRD:01078; MIM:153340; Vega:OTTHUMG00000167825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
T1; LEU1
Orthologs
See CD5 in MapViewer
Location:
11q13
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (61102458..61127852)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60869930..60895324)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD6 molecule Neighboring gene uncharacterized LOC105369326 Neighboring gene uncharacterized LOC105369325 Neighboring gene uncharacterized LOC105369324 Neighboring gene vacuolar protein sorting 37 homolog C (S. cerevisiae) Neighboring gene uncharacterized LOC105369327

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed

Go to the HIV-1, Human Interaction Database

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation IEA
Inferred from Electronic Annotation
more info
 
apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
cell recognition NAS
Non-traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
T-cell surface glycoprotein CD5
Names
T-cell surface glycoprotein CD5
CD5 antigen (p56-62)
lymphocyte antigen T1/Leu-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014207.3NP_055022.2  T-cell surface glycoprotein CD5 precursor

    See identical proteins and their annotated locations for NP_055022.2

    Status: VALIDATED

    Source sequence(s)
    AK292698, AP000437, BC027901, DB143341, X04391
    Consensus CDS
    CCDS8000.1
    UniProtKB/Swiss-Prot
    P06127
    Related
    ENSP00000342681, OTTHUMP00000236973, ENST00000347785, OTTHUMT00000396465
    Conserved Domains (2) summary
    smart00202
    Location:36133
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:279368
    SRCR; Scavenger receptor cysteine-rich domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    61102458..61127852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    60734232..60759595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)