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Bmi1 Bmi1 polycomb ring finger oncogene [ Mus musculus (house mouse) ]

Gene ID: 12151, updated on 22-Feb-2015
Official Symbol
Bmi1provided by MGI
Official Full Name
Bmi1 polycomb ring finger oncogeneprovided by MGI
Primary source
MGI:MGI:88174
See related
Ensembl:ENSMUSG00000026739; Vega:OTTMUSG00000011429
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmi-1; Pcgf4; AW546694
Orthologs
See Bmi1 in MapViewer
Location:
2 A3; 2 12.9 cM
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (18677018..18686629)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33355 Neighboring gene COMM domain containing 3 Neighboring gene cDNA sequence BC061194 Neighboring gene predicted gene 3363 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular process TAS
Traceable Author Statement
more info
PubMed 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
histone acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of immature T cell proliferation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
rostrocaudal neural tube patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
polycomb complex protein BMI-1
Names
polycomb complex protein BMI-1
B lymphoma Mo-MLV insertion region 1
polycomb group RING finger protein 4
polycomb group ring finger 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007552.4NP_031578.2  polycomb complex protein BMI-1

    See proteins identical to NP_031578.2

    Status: PROVISIONAL

    Source sequence(s)
    AL928680
    Consensus CDS
    CCDS15711.1
    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58
    Related
    ENSMUSP00000028071, OTTMUSP00000012215, ENSMUST00000028071, OTTMUST00000026762
    Conserved Domains (1) summary
    cd00162
    Location:1756
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    18677018..18686629
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497311.2XP_006497374.1  

    See proteins identical to XP_006497374.1

    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58
    Conserved Domains (1) summary
    cd00162
    Location:1756
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  2. XM_006497312.2XP_006497375.1  

    See proteins identical to XP_006497375.1

    UniProtKB/Swiss-Prot
    P25916
    UniProtKB/TrEMBL
    Q2LC58
    Conserved Domains (1) summary
    cd00162
    Location:1756
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...
  3. XM_011238945.1XP_011237247.1  

    See proteins identical to XP_011237247.1

    Conserved Domains (1) summary
    cd00162
    Location:2766
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably ...

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    18564450..18578495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)