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    Oprm1 opioid receptor, mu 1 [ Mus musculus (house mouse) ]

    Gene ID: 18390, updated on 19-Jul-2016
    Official Symbol
    Oprm1provided by MGI
    Official Full Name
    opioid receptor, mu 1provided by MGI
    Primary source
    MGI:MGI:97441
    See related
    Ensembl:ENSMUSG00000000766 Vega:OTTMUSG00000023338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mor; Oprm; muOR; MOP-R; MOR-1; M-OR-1; MOR-1O
    Summary
    This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    10 1.85 cM; 10 A2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (6758593..7038209)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (3308332..3557940, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K member 25 Pol protein-like Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene interaction protein for cytohesin exchange factors 1 Neighboring gene Cnksr family member 3 Neighboring gene uncharacterized LOC108167791

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    G-protein alpha-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    G-protein beta-subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    beta-endorphin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    beta-endorphin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    morphine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    morphine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    opioid receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-activating dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    behavioral response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to morphine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    eating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    opioid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of appetite ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of N-methyl-D-aspartate selective glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    mu-type opioid receptor
    Names
    MOP receptor
    mu opioid receptor MOR-1BI
    mu opioid receptor MOR-1P
    mu opioid receptor splice variant mMOR-1Z

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039652.2NP_001034741.1  mu-type opioid receptor isoform MOR-1C

      See identical proteins and their annotated locations for NP_001034741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1C) lacks an exon in the 3' coding region, compared to variant MOR-1U. The resulting isoform (MOR-1C), is shorter than isoform MOR-1U.
      Source sequence(s)
      AC153981, AF062753, AK038389
      Consensus CDS
      CCDS56687.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000101236, OTTMUSP00000027212, ENSMUST00000105611, OTTMUST00000056572
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    2. NM_001302793.1NP_001289722.1  mu-type opioid receptor isoform MOR-1

      See identical proteins and their annotated locations for NP_001289722.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1) lacks several 3' coding exons and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1) has a shorter and distinct C-terminus compared to isoform MOR-1U. This variant likely represents the major transcript of this gene.
      Source sequence(s)
      AC153981, AC164171, AF062753
      Consensus CDS
      CCDS78787.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000101232, OTTMUSP00000027194, ENSMUST00000105607, OTTMUST00000056549
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    3. NM_001302794.1NP_001289723.1  mu-type opioid receptor isoform MOR-1G

      See identical proteins and their annotated locations for NP_001289723.1

      Status: REVIEWED

      Description
      Transcript Variant: has an alternate exon in place of the 5'-most exon, lacks several 3' coding exons, and contains an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1G) has shorter and distinct N- and C-termini compared to isoform MOR-1U.
      Source sequence(s)
      AC164171, AF062755
      Consensus CDS
      CCDS78783.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000117950, OTTMUSP00000027192, ENSMUST00000147171, OTTMUST00000056547
      Conserved Domains (2) summary
      pfam00001
      Location:26268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:24213
      7tm_4; Olfactory receptor
    4. NM_001302795.1NP_001289724.1  mu-type opioid receptor isoform MOR-1M

      See identical proteins and their annotated locations for NP_001289724.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1M) has an alternate exon in place of the 5'-most exon compared to MOR-1U. The resulting isoform (MOR-1M) has a shorter and distinct N-terminus compared to isoform MOR-1U.
      Source sequence(s)
      AF062755, AK038389
      Consensus CDS
      CCDS78784.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000101240, OTTMUSP00000027193, ENSMUST00000105615, OTTMUST00000056548
      Conserved Domains (2) summary
      pfam00001
      Location:26268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:24213
      7tm_4; Olfactory receptor
    5. NM_001302796.1NP_001289725.1  mu-type opioid receptor isoform MOR-1N

      See identical proteins and their annotated locations for NP_001289725.1

      Status: REVIEWED

      Description
      Transcript Variant: has an alternate exon in place of the 5'-most exon and lacks an alternate 3' coding exon compared to variant MOR-1U. The resulting isoform (MOR-1N) has shorter and distinct N- and C-termini compared to isoform MOR-1U.
      Source sequence(s)
      AF062755, AK038389
      Consensus CDS
      CCDS78785.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000053498, OTTMUSP00000027215, ENSMUST00000063036, OTTMUST00000056575
      Conserved Domains (2) summary
      pfam00001
      Location:26268
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:24213
      7tm_4; Olfactory receptor
    6. NM_001304937.1NP_001291866.1  mu-type opioid receptor isoform MOR-1A

      See identical proteins and their annotated locations for NP_001291866.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1A) lacks 3' exons and its 3' terminal exon extends past a splice site that is used in variant MOR-1U. It encodes isoform MOR-1A which is shorter and has a distinct C-terminus, compared to isoform MOR-1U.
      Source sequence(s)
      AC153981
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000101227, OTTMUSP00000027200, ENSMUST00000105602, OTTMUST00000056557
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    7. NM_001304938.1NP_001291867.1  mu-type opioid receptor isoform MOR-1B1

      See identical proteins and their annotated locations for NP_001291867.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B1) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.
      Source sequence(s)
      AC153981, AC164171
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000101230, OTTMUSP00000027203, ENSMUST00000105605, OTTMUST00000056561
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    8. NM_001304948.1NP_001291877.1  mu-type opioid receptor isoform MOR-1B2

      See identical proteins and their annotated locations for NP_001291877.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1B2) lacks 3' exons and includes an alternate penultimate exon, compared to variant MOR-1U, resulting in a novel 3' coding region and 3' UTR. It encodes isoform MOR-1B1 which has a distinct C-terminus, compared to isoform MOR-1U.
      Source sequence(s)
      AC153981, AC164171
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000114342, OTTMUSP00000027199, ENSMUST00000154906, OTTMUST00000056556
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    9. NM_001304950.1NP_001291879.1  mu-type opioid receptor isoform MOR-1D

      See identical proteins and their annotated locations for NP_001291879.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1D) differs in the 3' UTR and has multiple coding region differences, compared to variant MOR-1U, one of which results in a frameshift. The resulting protein (isoform MOR-1D) has a distinct C-terminus and is shorter than isoform MOR-1U.
      Source sequence(s)
      AC153981, AC155718
      Consensus CDS
      CCDS78788.1
      UniProtKB/Swiss-Prot
      P42866
      Related
      ENSMUSP00000060329, OTTMUSP00000027216, ENSMUST00000052751, OTTMUST00000056576
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    10. NM_001304955.1NP_001291884.1  mu-type opioid receptor isoform MOR-1U

      See identical proteins and their annotated locations for NP_001291884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (MOR-1U) encodes the longest isoform (MOR-1U).
      Source sequence(s)
      AC153981, AC155718
      UniProtKB/Swiss-Prot
      P42866
      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      6758593..7038209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313828.1XP_017169317.1  

      Related
      ENSMUSP00000120187, OTTMUSP00000027214, ENSMUST00000123861, OTTMUST00000056574
    2. XM_017313829.1XP_017169318.1  

    3. XM_017313826.1XP_017169315.1  

      Related
      ENSMUSP00000077704, OTTMUSP00000027204, ENSMUST00000078634, OTTMUST00000056562
    4. XM_017313827.1XP_017169316.1  

      Related
      ENSMUSP00000000783, OTTMUSP00000027205, ENSMUST00000000783, OTTMUST00000056563
      Conserved Domains (2) summary
      pfam00001
      Location:85336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor
    5. XM_006512437.3XP_006512500.1  

      Conserved Domains (2) summary
      pfam00001
      Location:91336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:77281
      7tm_4; Olfactory receptor

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011013.1: Suppressed sequence

      Description
      NM_011013.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.