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TUBG1 tubulin, gamma 1 [ Homo sapiens (human) ]

Gene ID: 7283, updated on 26-Aug-2014
Official Symbol
TUBG1provided by HGNC
Official Full Name
tubulin, gamma 1provided by HGNC
Primary source
HGNC:12417
See related
Ensembl:ENSG00000131462; HPRD:01853; MIM:191135; Vega:OTTHUMG00000180277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBG; GCP-1; CDCBM4; TUBGCP1
Summary
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
See TUBG1 in Epigenomics, MapViewer
Location:
17q21
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (42609340..42615238)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40761358..40767256)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CoA synthase Neighboring gene PSMC3 interacting protein Neighboring gene MLX, MAX dimerization protein Neighboring gene family with sequence similarity 134, member C Neighboring gene high mobility group box 3 pseudogene 27 Neighboring gene tubulin, gamma 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Pr55(Gag) gag Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 PubMed
Tat tat HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type PubMed
tat HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria PubMed
Vpr vpr HIV-1 Vpr-expressing HeLa cells stained with centriole markers pericentrin, gamma-tubulin, and Cen2 contain multiple pairs of centrioles scattered in the perinuclear region, indicating Vpr causes the accumulation of multiple centrosome-like structures PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
GTP catabolic process IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
microtubule nucleation IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
protein polymerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
cell leading edge IEA
Inferred from Electronic Annotation
more info
 
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic microtubule IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
gamma-tubulin complex TAS
Traceable Author Statement
more info
PubMed 
nonmotile primary cilium IEA
Inferred from Electronic Annotation
more info
 
pericentriolar material IEA
Inferred from Electronic Annotation
more info
 
polar microtubule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tubulin gamma-1 chain
Names
tubulin gamma-1 chain
tubulin, gamma polypeptide
gamma-tubulin complex component 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033886.1 

    Range
    5001..10899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001070.4NP_001061.2  tubulin gamma-1 chain

    See proteins identical to NP_001061.2

    Status: REVIEWED

    Source sequence(s)
    AC067852, BC000619, BG167819, DB028144
    Consensus CDS
    CCDS11433.1
    UniProtKB/Swiss-Prot
    P23258
    Related
    ENSP00000251413, OTTHUMP00000263808, ENST00000251413, OTTHUMT00000450548
    Conserved Domains (2) summary
    cd02188
    Location:3435
    Blast Score: 2388
    gamma_tubulin; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin ...
    PLN00222
    Location:1451
    Blast Score: 2243
    PLN00222; tubulin gamma chain; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    42609340..42615238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    36525950..36531846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    40997122..41003018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)