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Ptpn6 protein tyrosine phosphatase, non-receptor type 6 [ Mus musculus (house mouse) ]

Gene ID: 15170, updated on 8-Dec-2014
Official Symbol
Ptpn6provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 6provided by MGI
Primary source
MGI:MGI:96055
See related
Ensembl:ENSMUSG00000004266; Vega:OTTMUSG00000038210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
me; hcp; Hcph; Ptp1C; SHP-1; 70Z-SHP; SH-PTP1; PTPTY-42
See Ptpn6 in Epigenomics, MapViewer
Location:
6 F2; 6 59.17 cM
Exon count:
17
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 6 NC_000072.6 (124720707..124738709, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene microRNA 141 Neighboring gene microRNA 200c Neighboring gene gene rich cluster, C10 gene Neighboring gene U7 small nuclear RNA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
natural killer cell lectin-like receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
abortive mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
natural killer cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet formation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
alpha-beta T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein phosphatase non-receptor type 6
Names
tyrosine-protein phosphatase non-receptor type 6
motheaten
protein-tyrosine phosphatase 1C
hematopoietic cell protein-tyrosine phosphatase
NP_001071173.1
NP_038573.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077705.2NP_001071173.1  tyrosine-protein phosphatase non-receptor type 6 isoform b

    See proteins identical to NP_001071173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AK150509, AK151077, BY035180
    Consensus CDS
    CCDS51908.1
    UniProtKB/Swiss-Prot
    P29351
    UniProtKB/TrEMBL
    Q3UB72
    UniProtKB/TrEMBL
    Q3UCJ0
    Related
    ENSMUSP00000129124, OTTMUSP00000055279, ENSMUST00000171549, OTTMUST00000098376
    Conserved Domains (4) summary
    cd09931
    Location:111217
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:6103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:245516
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:275516
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_013545.3NP_038573.2  tyrosine-protein phosphatase non-receptor type 6 isoform a

    See proteins identical to NP_038573.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 2. It encodes isoform a, which has a shorter and distinct N-terminus, compared to isoform b.
    Source sequence(s)
    AC164157, AK151077, AK151623
    Consensus CDS
    CCDS39628.1
    UniProtKB/Swiss-Prot
    P29351
    UniProtKB/TrEMBL
    Q3UB72
    Related
    ENSMUSP00000108103, OTTMUSP00000055277, ENSMUST00000112484, OTTMUST00000098374
    Conserved Domains (4) summary
    cd09931
    Location:109215
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:3101
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:243514
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:273514
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000072.6 

    Range
    124720707..124738709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 

    Range
    126402436..126420442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)