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Nog noggin [ Mus musculus (house mouse) ]

Gene ID: 18121, updated on 8-Dec-2014
Official Symbol
Nogprovided by MGI
Official Full Name
nogginprovided by MGI
Primary source
MGI:MGI:104327
Locus tag
RP23-205A9.1
See related
Ensembl:ENSMUSG00000048616; Vega:OTTMUSG00000001321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Location:
11 C; 11 54.34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (89300638..89302559, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 25 Neighboring gene diacylglycerol kinase, epsilon Neighboring gene predicted gene 525 Neighboring gene RIKEN cDNA 4932411E22 gene Neighboring gene ankyrin-repeat and fibronectin type III domain containing 1 Neighboring gene predicted gene, 34619

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by BMP, organism-specific biosystem (from REACTOME)
    Signaling by BMP, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • TGF Beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF Beta Signaling Pathway, organism-specific biosystemThe Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiat...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
anatomical structure formation involved in morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
axial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell differentiation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
cellular response to BMP stimulus IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic skeletal joint morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
endoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
face morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb development ISO
Inferred from Sequence Orthology
more info
 
lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
middle ear morphogenesis ISO
Inferred from Sequence Orthology
more info
 
motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
neural plate morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glomerulus development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
somatic stem cell maintenance ISO
Inferred from Sequence Orthology
more info
 
somite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development IDA
Inferred from Direct Assay
more info
PubMed 
ureteric bud formation IDA
Inferred from Direct Assay
more info
PubMed 
urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008711.2NP_032737.1  noggin precursor

    See proteins identical to NP_032737.1

    Status: VALIDATED

    Source sequence(s)
    AK146488, BC132527, CA752122
    Consensus CDS
    CCDS25236.1
    UniProtKB/TrEMBL
    A2RTJ4
    UniProtKB/Swiss-Prot
    P97466
    Related
    ENSMUSP00000061427, OTTMUSP00000001311, ENSMUST00000061728, OTTMUST00000002649
    Conserved Domains (1) summary
    pfam05806
    Location:9232
    Noggin; Noggin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    89300638..89302559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p2 NOD/ShiLtJ

Genomic

  1. NT_187003.1 

    Range
    2436876..2438797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    98919523..98921373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)