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LMO4 LIM domain only 4 [ Homo sapiens (human) ]

Gene ID: 8543, updated on 21-May-2015
Official Symbol
LMO4provided by HGNC
Official Full Name
LIM domain only 4provided by HGNC
Primary source
HGNC:HGNC:6644
See related
Ensembl:ENSG00000143013; HPRD:09122; MIM:603129; Vega:OTTHUMG00000010248
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Orthologs
See LMO4 in MapViewer
Location:
1p22.3
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (87328468..87348923)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (87794151..87814606)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1140 Neighboring gene uncharacterized LOC101927844 Neighboring gene uncharacterized LOC105378832 Neighboring gene long intergenic non-protein coding RNA 1364 Neighboring gene uncharacterized LOC105378833

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.
NHGRI GWA Catalog
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of protein complex assembly IEA
Inferred from Electronic Annotation
more info
 
neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
regulation of cell activation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell fate specification IEA
Inferred from Electronic Annotation
more info
 
spinal cord association neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
ventral spinal cord interneuron differentiation IEA
Inferred from Electronic Annotation
more info
 
ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
LIM domain transcription factor LMO4
Names
LIM domain transcription factor LMO4
LIM domain only protein 4
LIM-only 4 protein
LMO-4
breast tumor autoantigen

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006769.3NP_006760.1  LIM domain transcription factor LMO4

    See identical proteins and their annotated locations for NP_006760.1

    Status: REVIEWED

    Source sequence(s)
    AC092392, AI962216, AW162477, BU580860, BU619915, U24576
    Consensus CDS
    CCDS713.1
    UniProtKB/Swiss-Prot
    P61968
    Related
    ENSP00000359575, OTTHUMP00000011905, ENST00000370544, OTTHUMT00000028264
    Conserved Domains (2) summary
    cd09386
    Location:2377
    LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
    cd09387
    Location:87141
    LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    87328468..87348923
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271291.2XP_005271348.1  

    See identical proteins and their annotated locations for XP_005271348.1

    UniProtKB/Swiss-Prot
    P61968
    Conserved Domains (2) summary
    cd09386
    Location:2377
    LIM1_LMO4; The first LIM domain of LMO4 (LIM domain only protein 4)
    cd09387
    Location:87141
    LIM2_LMO4; The second LIM domain of LMO4 (LIM domain only protein 4)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    87909001..87929485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)