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    Fes feline sarcoma oncogene [ Mus musculus (house mouse) ]

    Gene ID: 14159, updated on 3-Jul-2016
    Official Symbol
    Fesprovided by MGI
    Official Full Name
    feline sarcoma oncogeneprovided by MGI
    Primary source
    MGI:MGI:95514
    See related
    Ensembl:ENSMUSG00000053158 Vega:OTTMUSG00000058666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FPS; c-fes; AI586313; BB137047
    Orthologs
    Location:
    7 D3; 7 45.65 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (80377758..80387954, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (87522644..87532832, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene furin (paired basic amino acid cleaving enzyme) Neighboring gene serine hydroxymethyltransferase 2 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    centrosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule bundle formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mast cell degranulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    proto-oncogene c-Fes
    proto-oncogene tyrosine-protein kinase Fes/Fps
    tyrosine kinase Fps/Fes
    NP_034324.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010194.2NP_034324.2  tyrosine-protein kinase Fes/Fps

      See identical proteins and their annotated locations for NP_034324.2

      Status: VALIDATED

      Source sequence(s)
      AC136740, AK143639, BC038130
      Consensus CDS
      CCDS39999.1
      UniProtKB/Swiss-Prot
      P16879
      UniProtKB/TrEMBL
      Q8CGG9
      Related
      ENSMUSP00000079733, OTTMUSP00000075133, ENSMUST00000080932, OTTMUST00000144100
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:564814
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      80377758..80387954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540604.3XP_006540667.1  

      See identical proteins and their annotated locations for XP_006540667.1

      UniProtKB/Swiss-Prot
      P16879
      Related
      ENSMUSP00000146041, OTTMUSP00000075136, ENSMUST00000206728, OTTMUST00000144104
      Conserved Domains (4) summary
      cd07685
      Location:7239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      pfam07714
      Location:561814
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:564814
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006540605.2XP_006540668.1  

      Conserved Domains (1) summary
      cl12013
      Location:7239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature