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    Nos3 nitric oxide synthase 3, endothelial cell [ Mus musculus (house mouse) ]

    Gene ID: 18127, updated on 14-Jul-2015
    Official Symbol
    Nos3provided by MGI
    Official Full Name
    nitric oxide synthase 3, endothelial cellprovided by MGI
    Primary source
    MGI:MGI:97362
    See related
    Ensembl:ENSMUSG00000028978; Vega:OTTMUSG00000024082
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eNOS; Nos-3; ecNOS; 2310065A03Rik
    Orthologs
    See Nos3 in Epigenomics, MapViewer
    Location:
    5 A3; 5 11.32 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (24364819..24384474)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (23870637..23890292)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 33476 Neighboring gene predicted gene 15589 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene autophagy related 9B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 8 Neighboring gene cyclin-dependent kinase 5 Neighboring gene acid-sensing (proton-gated) ion channel 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FMN binding IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADPH-hemoprotein reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
     
    arginine binding ISO
    Inferred from Sequence Orthology
    more info
     
    beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nitric-oxide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric-oxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrobiopterin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    arginine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of muscle hyperplasia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oxidation-reduction process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of guanylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasodilation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of blood vessel size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of systemic arterial blood pressure by endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of the force of heart contraction by chemical signal IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    smooth muscle hyperplasia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell ISO
    Inferred from Sequence Orthology
    more info
     
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    nitric oxide synthase, endothelial
    Names
    EC-NOS
    NOS type III
    NOSIII
    cNOS
    constitutive NOS
    endothelial NOS
    endothelial nitric oxide synthase
    NP_032739.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008713.4NP_032739.3  nitric oxide synthase, endothelial

      See identical proteins and their annotated locations for NP_032739.3

      Status: VALIDATED

      Source sequence(s)
      AK077896, AW489695, U53142
      Consensus CDS
      CCDS19117.1
      UniProtKB/Swiss-Prot
      P70313
      UniProtKB/TrEMBL
      Q8C5P3
      Related
      ENSMUSP00000030834, OTTMUSP00000028591, ENSMUST00000030834, OTTMUST00000058885
      Conserved Domains (4) summary
      COG0369
      Location:5111158
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:67479
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:521697
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:7611163
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      24364819..24384474
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535639.2XP_006535702.1  

      Conserved Domains (4) summary
      COG0369
      Location:4591106
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      cd00795
      Location:15427
      NOS_oxygenase_euk; Nitric oxide synthase (NOS) eukaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N ...
      pfam00258
      Location:469645
      Flavodoxin_1; Flavodoxin
      cl06868
      Location:7091111
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      21311457..21334226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)